Wor
C.

_Progress

1,Biochemistry fection (Gordon Could)
a.__Electrophoretic Studv of the Combination of Fission Products

withSerum Proteins

Molly

Maree,

Harry

Foreman,

Gordon

Gould):

Preliminary results on sr®9 have yielded the following tentative
a
se

results:

1)

at 30 minutes after intravenous injection, sr89 was distri-

buted among all serum proteins except albumin, with possibly a slight increase
in the PB globulin fraction.

At 2 hours, there was an increase in concentration

at or near to the y globulin fraction,
2)

Although Sr appears to be bound to protein during electro-

phoresis it was found to move during thestaining and washing
ng é rationstak
Classification changed to
Bal)
6c

it imperative to do radioautograbh s#uer
b.

Absorption and 14%

ise

Gould, Virginia Lotz, Edith Lill»):

tifs tkthda

KM.

;

tbe.

Z

Claef

OP
De

ZLLee

66) ox

(Signafute of person making ths chang3, and date)
Two experiments have been carried out to confirm, the previously

reported effect of dietary DHC on liver cholesterol concentration.

In the first,

plasma cholesterol levels were lower in the DHC fed animals (46.8%) than in the

controls (71.4 mg %).

Liver analyses were uncertain because of technical diffi-

culties and the results are inconclusive.

In the second experiment, a 2% DHC

diet was fed for 10 days and the liver levels were found to be lower (2.17 mg/em,

range of 1.99-2.35) than in the control group (2.55 mg/gm, range of 2.16-3.25).
The serum values were also slightly lower, 54.3% for the DHC group, 64.2 for the
controls.

Although this difference was not as marked as in the original experi-

ment, the decrease in level does seem to be a definite and consistent effect and
one not observed with sitosterol.
c,

‘,
hn

Tests of New Chelatine Arents.

(H, Foreman, C, Finnegan):

Two new chelating agents were tested this month and appear suffi-

oT ciently interesting to be worthy of further investigation.

SNcS
SS

Both were sent to us

/.

Select target paragraph3