16
FEFECT=
bor
of Group PE CA hineinacs. . percent of Cipeuzs
Tl i Amertean-). ad liede of (iro vy v
'Ttirik). Three peapie ho €rronp Poona one
in Group TLeompla ned et tehiyg and cue ¢
of the eves and dicrimuetion
These init ae =k
and eve symptoms were most Jikely due cor
radiation since: Hund viduals who experienced
the initial symptoms Jater developed
Furthermore the nitiad “ymptomatologs
4
these people was simitar te that reported 1 on
stances of accidental laboratory overexposure
to radiation, deseribed on Chapter EIT
dr a-
possible, however, that chemical irritunan os
the fallout matermai sheet was predomanan: ts
highly alkaline calenim oxule, Wav have ie.
centuated the initial vi. ptoms
About two-th rds of Group |} were iauseated
during the first days upd one-tenth «ome
and had diarrhea, ‘One individual oy Crrony
IT was nauseated. fi, Groups PT and PV theve
were no gastrointestinal (GE) symptoms. lhe
information concerning “ymptoms was obtaines
by questioning "hrough an imterpreter ba ss
eral individuals Despite the repeated interrn
gations and the inev:table suggestion of the
tie
stories
remained corsistent
AIL GI symptoms sibsided by the thord nas
without theraps ind there was ne cecurrer ce
The presence. sever ty. aid duration of 1 at
sea, Vomiting, and diairrnea ure know?
te bent
a direct relationship to degree of exposure vn
probability of the rerovery CL. 2. Vt mod bos
of note that the ineidence of these ~sptom:
was correlated with ‘ie dose received and thar
there were NO castromitestinal Symptoms 4
Group TV. the largest group, which
only l4r
cecerse
(rl symptomatowgy nay lave cee
due to direet ino urv of the @r0 traet as obser. es
In animals aftes whole ody irradiation
or may have been ron speeic
following therapeuth
is is
7 ™
absense
radiation
Various other chnveae conditions which «ere
encountered diriug
die
ourse of opservi can
of the exposed groin. were not tae result
radiation exposure
VP} e cperdenee von
?
Node
RADIATION
eT,
exposure
~Hilse
3
Bytes
tliscussed below, were similar in
groups and it nonexposed imdi-
eds
2.4
Clinical Observation and Therapy
With Respect to Hematological
Findings
141
Clinical Observations and Leukocyte Counts
iugqnes
tioned radiation induced skin lesions (epilation
and conjunetis tis:
see Chapter
11!
interrogators,
\
Berweren [He 33rd and 48rd post-exposure
days. LO percent of the individuals in Group I
nad in tbsolute granulocyte level of 1000 per
The lowest count ob-erved during this period was 100 granulocytes /
noic millimeter or below.
During this interval the advisability of
mr.
giving
prophylactic
antibiotic
therapy
to
granuloeytopenic individuals was carefully con-
~udered.
However,
prophylactic
antibiotic
therapy was not instituted for the followmg
LALSOND
‘}) AL] :ndividuals were under continuous
medical observation so that infection would be
tiscevered in its earliest stages.
+2) Premature administration of antibiotics
nught
have obscured medical indications for
‘reatment, and might also have lead to the de-
velopment of drug resistant organisms mn inQviduas with a lowered resistance to infecfon
31 There was no accurate knowledge of the
cvumber of granuloeytes required by manto prevent infection with this type of granulocyto-
nena,
Che observed situation was not strictly com-
arable to agranulocytosis with an aplastic
Harrow as seen following knownlethal doses of
iadiition.
fn the latter instance, granulocytes
tall rapadds) with practieally none in circula-
non and ne evidence of granulocyte regeneraion when .nfection occurs (6).
In the pres-
ent group of individuals exposed to radiation,
ost count» reached approximately one-fourth
vormai value. but the fall to that level was
mitdua and the presence of immature granuwaves an the peripheral blood during the perhe