47 HEMATOLOGIC OBSERVATIONS Table 4.1.—Hematological Results, Marshallese Control Groups | No. or [NprvipuaLs <5 5-10 | 1-15 21-30 >50 14 4 ‘ 9 4 2 | NECTROPEE LYMPHOCYTE { 13.91281122 88/43 48/64 40/44 118 066128 93755 39/66 $255.1 4] cee eee eee veeeee cle fee eee [eee (10.8 8. 2.6 9.3 | 3$10646/56 | PLATELET 6.0150 52/43 3.8/3.4 B34} | 27.6 43.3 7092.8 48.4987, 429.382 17 10 7 8.9106: asiaa §.8)43 5643.8 4.2/3.3 3.7 4 9 | 2 4 7.9903) 4441290138 47/76 79/33 4.1562 4.4 3°12 | 3 7.5 4.7) 3.0/3.6 to] 37 3.6 21.3 35.4 0 4 7 2 3 | i 04° 9110.2 89 381 7.9 03) 4.9 51) 46 \ 49 46/3.5 comparable data were not available. Total leukocyte, neutrophile, lymphocyte, monocyte, platelet and eosinophile counts for the several exposure groups are given by day, by sex and age in Tables 4.2 to 4.5. The total white count, neutrophile, lymphoctyte and platelet counts at the times of maximum depression (averaged over the time during which counts were consistently the lowest) are shown in Tables 4.6 and 4.7 for each individual in Groups I and II respectively. Hematocrits for ull exposure groups are shown in Table 4.8. Hematological findings as a function of time and age are shownalso in Figures 4.1 to 4.8. The cumulative distribution curves for the various exposure groups, using the average of counts obtained over the period of maximum depression (days 39 to 51 for leukocytes; days 26 to 30 for platelets) are shown in Figures 4.9 to 4.12.* In the figures emphasis is placed on the separate blood elements rather than on the total lenkocyte count, since the componentelements have distinct and different time trends after irradiation. *In Group [V the cumulative distribution curve for platelet counts only is presented since hematoloical determinations in this group were not made during the day period, used for leukocyte comparisons among the other groups. 4.31 seeeee 24.5 33.7 42.0 423! 38.0 39.2 cece 8 7.5 | 28.0 38,3 3 5 creel HEMATOCRIT : { Grove Bi Grour A i Grou? B M F | M F i M F ' ene | cone 32)47 1 4.3 | 42.2 35.9 | 35.0 31.7 | 38.5 37.4 35.9 37.8 39) 39.7 38.7 | 35.0 36.2) 41,2 39.2 | 38.5 37.7 593, sex dependency of these endpoints are comparable to that in published data (9.10), with the exception of the platelets, on which previous 39 ta OT | i Group BiGroue A\Gnour, Biogoer AlGaovr BI Grove A M F | M F | M | F | M F | M F | 7 6 fee fee eee 16-20 41-53) 10 6 13] (1-20 31~40 WBC 1 Grour_A:Grour BI Grove A M F | M FIM F eee eee | eeeeeee 23.6 34.2 | 25.4 29.3 | 46.938.9! 46.2405 25.0 30.2 | 28.5 30.01 47.2 4.2 | 46.0 425 £21526 3.9, 3.2322 | cae 1 ! 27.4 3.5! 42.3 41.8 { 44.1 42.0 25.3 27.6 | 43.7 41.7 | 40,6 41.0 ‘ Hematological Findings, Group I. Rongelap The absolute neutrophile count of both the younger and older age groups fell during the second week to x value approximately 70 to 80 percent of that of the controls (see Fig. 4.1). NEUTROPHILES » 10° AG AcE POST EXPOSURE O«Y Fictre 4.1.—Seriai changes in ncutrophile counta af Group [ (Rongelap) for those less than 5 years and greater than 3 ycars of age. Following the depression of the total neutrophile count during the 2nd week, the values were tnstable until the 5th week. At this time the beginning of a second drop (p<0.01) was noted for both age groups, and a low value of approximately 50) percent of controls was