Ve present at the timeOPexposure, who died 2 vears after the accidentya2 78-vear-old man who radiation of the skin were seen in 12 cases which ease complicating diabetes, and: 3) a 3o-vear-oid burns. Numerous histopathological studies have been made,':'’ and the changes found have been consistent with radiation damage. At no time have died, 3 vears after exposure. of coronarvheart disman who died of acute varicella. + vears after exposure, who had received only 69 r, having been on Ailiggnae at the time ofthe fallout. There was no apparent relationship between anyof these deaths ind radiation exposure, and mortalityin the exposed group did not appear to be greater than in the unexposed population. It was difficult to-evaluate the effects on fertility. However, a numberof apparentiv normal babies were born during the +-vear geriod, and there has been no discernible fall in birth rate. A slightly higher number of miscarriages occurred in the exposed women than in the unexposed group; this will be further evaluated in the present report. No opacities of the lens or other eye changes have been found that could be related to radiation. Studies on height,weight, and bone age seemed to show slight of retardation in growth and development iin the exposed children. However, the small number ofchildren involved, and a later finding that exact ages of some ofthe children were in doubt, has resulted in a re-evaluation of these data based on more reliable age determinations. me BETA IRRADIATION OF THE SKIN It was impossible to get an accurate estimate of the radiation dose to the skin. Beta burns of the skin and epilation appeare@ about 2 weeksafter exposure, largely on parts.of the body noggovered by clothing, About 90% of the people had these showed varying degrees of pigment aberrations, scarring, and atrophy at the site of the former changes been observed either grossly or microscopicaily indicative of malignant or premalignant change. Spotty epilation on the heads was short lived. regrowth of hair occurring about 3 months after exposure.and complete regrowth af normal hair bv six months. No further evidence of epil a- tion has been seen. An interesung observation was the appearance of a bluish-brown pigmentation of the semilunar areas of the Hngernails and toenails in about 90% of the people, beginning about 3 weeksafter exposure. By 6 months, thig. pigmentauanhad largely grown out with the nail andhad disappearedin most cases. The cause of this phenomenon has not been explained. INTERNAL IRRADIATION é Radiochemical analyses of numerous urine samples of the exposed population showed internal absorption of radioactive materials, probably brought about largely through eating and drink- ing contaminated food and water and to lesser extent through inhalation. During the first few days when the bodylevels were at their highest, the maximum permissible concentrations were ap- proached or slightly exceeded only in the case of strontium-89 and theisotopes of iodine. The con- centrations were believed ta be too low toresult in any serious effects. Body levels felFeapidly, so that burns, and a smaller number developed spotty by 2 and 3 years past exposure, they Were far below the accepted maximum permissible levely. by 6 epilation of the scalp. Mgt of the lesians were superficial; they-exhibité#t pigmentation-and dry, ' gaopthsactivity in the urine wasbarely detectable. scaly desquamagion, and were associated with The-return of the Rongelapese to their home little pain. Rapid h g and repigmentation «Jsland:(which after careful survey was considered followed. Some lesiatlswere deeper, showed wet -~gafe fot habitation, despite a persisting lowlevel of desquamation, and were more painful. A few radioactive contamination) was reflected in rise burns became secondarily infected and had to be". in their body burdens and increased urinary extreated with antibiotics. Repigmentation ofthe 5 ,_ cpetiog. of certain: radionvwtlides. Béginning in lesions gradually took place in mostinstances, and * 1957, gamma spectroscopyby use of a low-level the skin appeared normal withia a few weeks. . counting chamber was added to the techniques of However, in about 15% of the people, deeper " radiotheinical analysis. This, along with radiolesions, particularly noted on the dorsum of the chemical analysis of urine samples, showed an infeet, continued to showlack of repigmentation crease in body burdens of cesium-137 by factors of with varying degrees of scarring and atrophyof up to 100 and of strontium-90 by a factor of10 to the skin. At + years the onlyresidual effects of beta 20, and some increase also in zinc-65, since the re- 1185993

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