~2of injury and the clinical manifestations are -roportionate to the dose. is particularly true of the syndromes of whole body radiation. I repeat, highly dependent on doseand time after exposure. description, This The latter is and There ts no simple The problem is subtle and complex and one must always bear dose and time in mind. THE SYNDROMES FRCM TOTAL BODY PENETRATING RADIATIONS The dose dependent syndromes resulting from total body exposure in the manumal have been described in detail and I shall only summarize then here, furtker details one is referred to the following references (1-12). For After large doses (approximetely 6000 r or more) the central nervous system syndrome wi.ich can be abbreviated CNS is produced, being irradiated or after some hours. Death may occur under the beam while “he clinical picture is characterized by hyperexcitability, disorders of equilibrium, incoordination, respiretory distress and intermittent stupor. Convulsions may preceed death. this syndrome are elways uniformly fatal. Doses capable of producing If an cecasional animal, and presumably man, survives this CNS he has yet to experience the gastrointestinel syndrome (GIS), which when produced by doses in excess of 1500 r is always fatal within three to nine days for mammals, laboratory animals, Presumably man also will respond in a comparable manner cs The GIS is so named because of the marked nausea, vomiting, diarrhea, and denudation of the lining of the small bowel, fatal syndrome in most laboratory animals, The GIS is a uniformly If the short duration GIS of a few hours resulting from lover doses, does not produce the three to nine day death, the survivors of this syndrome have yet to experience the sequelae of bone marrow depression which has been termed the hemopoietic syndrome (HS). The HS is not necessarily fatal. It is the clinical cicture that is seen in the lethal range for all mammals and in gereral the 50% lethal dose values reported, represent the Lp°0 for the sequela of henopoletic depression — namely granulocytopenia, depressed defenses ageinst infec- tion, thrombopenia, amd anezia with the pessible resulting infections, diffuse pur- DOE ARCHIVES