44 A review of the medicalstatus of the people during the previous year revealed that few majorillnesses had occurred and no epidemics of infectious diseases. No illnesses were reported in the exposed group which mightbe related to radiation exposure. No deaths had occurred except in two infants. One baby born of unexposed parents died of a congenital malformation (anencephaly). Only a few miscarriages had occurred and the incidence was nogreaterin the exposed womenthanin the unexposed. Thus, the suggestive trend of increased numberof miscarriages andstillbirths in the exposed womenreported for previous years was not apparent during the past two years. Physical examinations showednoacute illnesses present nor any diseases which could bedirectly associated with radiation effects. The incidence of various diseases was generally the samein the ex- posed and unexposed groups. It was noted that several of the older people, particularly in the exposed group, were becoming quite feeble and helpless. Residual! skin changes in areas previously show- ing lesions from fallout were present with certainty in about 10 people. The changes noted were principally atrophy, scarring, and pigment aberrations. None of these cases showed anvevidence of chronic radiation dermatitis or malignant change. The appearance of pigmented maculae and moles in previously irradiated areas of the skin was more common this year than noted in the past. it is believed. However, these pigmented lesions appeared quite benign. Theywill be scrutinized closely on future survevs. The incidence of diabetes in both exposed and unexposed people appeared to be higher than found in the United States. Dental examinations revealed a high incidence of caries in the younger people and periodontoclasia in the older people. No difference was noted between the exposed and unexposed groupin regard to dental!findings. Careful examinationsfor the detection of such late effects of radiation as cancer and leukemia re- vealed no evidence of these malignancies in any of the people, exposed or unexposed. Growth and development data from 1958 through 1960 were reviewed for the children. These data revealed a distinct tendency for the exposed boys of ages <(12 to be shorter than the unexposed males of comparable chronological ages. This was prominentin the boys exposed before 6 years of age, and most markedin those exposed at 12 to 18 months. A similar butless distinct trend was noted for body weight amongthe exposed boys. These trends were not noted amongthe exposedgirls. However, skeletal maturation studies (roentgeno- grams of left hand and wrist) showed trendssuggestive of inferior skeletal maturation in both male and female exposed children compared with unexposed children, although the differences did not reach thelevel of statistical significance. A high degree of correlation was found between retarda- tion in skeletal age and inferiority in statural growth. Ofspecific interest was the groupof children now 8 years old who had been exposed to fallout at ages 12 to 18 months; this group showed the most marked retardation in physical and skeletal growth. Similar studies comparing growth and development in children of exposed parents and in children of unexposed parents showed that the male offspring of exposed parents were smallerin stature at all ages then those of unexposed parents. The most marked differences occurred at 1, 3. and 4+ vears of age, and in those born <2 years after the fallout. In order to investigate the possible effect of radi- ation in inducing premature aging, variouscriteria were measured or estimated during physical examtnations (visual ecultv, accommodation, arcus senilis, graying of hair, balding, skin looseness, skin elasticity. senile skin changes, blood pressure, peripheral arteriosclerosis, and neuromuscular function). No apparent effect of radiation was noted, since measurements were not greatly different in the exposed and unexposed age groups and were similar to the measurements previouslyreported.’ However, the study is of interest with regard to the measurementofbiological aging, since the various criteria showed definite age dependenttrends, and, by combiningthe scores on a percentage basis, an over-all biological age score was determined. Slit-lamp observations for cataracts were not carried out on this survey, but previous surveys had shownno evidence of induced opacities of the lens. Genetic studies have not been specifically conducted. Examinations of children of exposed parents have revealed little in the way of congenital anomalies. One baby born of an exposed

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