—~ Table 1. Substitution frequency of isoleucine for other amino acids in the globin of human hemoglobin from 25 Marshall Island people. Age at Age at Exposure exposure present Sex 3R 10R 175 R " 15 mo 30 yr. 21 yr. 50 yr. M M 19.79 3.58 21 32 22 47 Sample 18R 24R Substitution Average + frequency (x 10°) SEM (X 107°) 33R 35R 42R 71R " " " " " . 24 yr. 13 yr. 44 yr. 33 yr. yr. yr. yr. yr. F F F F 4.74 5.19 10.40 8.29 6A 8A 69 R . 1 yr. 17 mo 21 yr. 21 yr. M F 6.98 12.93 44a 45A S1A 813uU 15 929U 836 839 8410 846 8671 868L 944) 1547 1549 HC yoke " " " OR " . " 1 12 2 27 yr. yr. yr. yr. 3 yr. 31 yr. 7 yr. 23 yr. 51 yr. 27 yr. 20 yr. 41 yr. F 3.56 51 yr. " * 46 yr. 51 yr. 49 yr. 60 yr. 21 yr. F F F F M F M 8.81 + 1.96 5.94 + 1,92 3.37 2.17 3.47 2.45 " " M 4.04 3.65 2.12 M F M 46 yr. " " M F F 5.06 13.45 24 yr. 35 yr. 41 yr. " " F F 1.89 2.4) 2.12 4.35 3.93 7.15 1.57 3.20 + 1.52