ium Lung
nd. Hyg.
termination
surements of
ent of Radi.
mic Energy;
603.
APPENDIX C
j
i
"Evaluation
g Systemic
§
- 32, 58
4
MEDICAL FOLLOW-UP OF PATIENT NO. 2
F
The ApplicaDeterminat to,
rt V.
erties of
urden in
ty in Man
y, Vienna,
M-704
nium Body
mos Sci(April
704 Code
ns,”
2 NE ER mapa
opes," Brit.
heginning in the spring of 1942, patient No. 2
was
exposed
to
uranium halides while attempting to
uranium tetrafluoride to the metallic state.
reduce
Patient No,
2, one of several nonmilitary members of
the CUFF group, worked at Los Alamos from February 3,
1944,
to August
16,
1944.
He subsequently worked at
tests including pulmonary function, sputum cytolOgy, tantalum insufflation, bronchoscopy, and lung
tomography.
Cytological examinations based on
sputum, bronchoscopic washings, and brush specimens showed no metaplasia in cells exfoliated from
the bronchial tree.
There were some indications
other installations where he was not exposed to
of an inflammatory process which could be compat-
raudivactive materials.
ible with an underlying bronchial growth.
However, late in 1946, he
Tomo-
was exposed to beryllium oxide and beryllium chlo-
graphic tests verified the previous findings of
ride.
a well demarcated, simple lesion located in the
In
1948, he was engaged in hot-pressing ura-
nium powder with hardening agents.
In 1952, he
right lower lung.
Fiber-optic bronchoscopy indi-
worked with catalytic agents but had no significant
cated no abnormal changes in the lung within small
exposure to toxte chemicals.
bronchioles (to about 3 mm).
In 1954, he was
exposed to sodium vapors as well as compounds of
chlorine, arsenic, and antimony.
Very often these
Cytological study
of specimens obtained by pinch biopsy was also negative.
Results of the tantalum insufflation radi-
materials were weighed in the open in crucibles
ography indicated no intrusion on the bronchial tree
that were evacuated and then fired.
or deposition defects.
The crucibles
were opened without the benefit of hoods or dryboxes.
In 1960, he worked with cadmium selenite in
a vacuum system but probably was not exposed to
toxic materials.
Since 1965, he has been involved
Because of the demonstrable growth of the lesion since 1965, the attending physicians decided to
perform a simple lobectomy, and on May 17, 1971, the
right lower lobe was removed.
Histological sections
in the manufacture of electronic instruments used
of the tumor and regional lymph nodes were made, and
to detect hydrocarbons.
samples of the tumor, normal lung, regional lymph
During the medical examination in 1966, a
nodes, and bone were sent to several laboratories
small, coin-sized lesion was noted in the right
for radioactive assay and radiographic studies.
lower lung.
Histologically, the neoplasm was a classical benign
A previous chest roentgenogram made in
1960 had been normal.
in
The follow-up examination
1969 confirmed the lung abnormality which showed
no detectable change in size.
In a roentgenogram
hamartoma (derived from residual embryonic cells)
containing considerable adult cartilaginous and epithelial cells.
Interestingly, the regional lymph
taken fn March 1971, the lesion had nearly doubled
nodes were perfectly normal histologically with no
in size and then had an outside diameter of about
signs of cellular damage despite the relatively high
Som,
radioactivity.
Following consultation between attending
Phystcfans,
the individual concerned, and staff
of
the AEC's Division of Biology and Medicine, the
Paticnt was admitted on May 4, 1971, to a large
hospital
in the eastern United States for further
diagnostic studies.
During the following several
davs, he was subjected to a series of diagnosric
Patient No. 2 is currently in good health and
returned to Los Alamos with other members of the
UPPU group for additional study in November 1971.
We believe it is worthwhile to point out that there
is concern and interest for these subjects even
though many years have passed since they worked with
29