disturbances have not been searchedfor,
and, in many experiments, the pathologic findings have not been carefully
enumerated. Recent studies have questioned the validity of the concept of
nonspecific shortening of the life
span.1213
There are no data on human beings
that support the concept of nonspecific
aging acceleration as a late consequence
of irradiation. The studies reported here
concern certain aspects of aging of skin
and hair in a Hiroshima population.
These studies fail to show any evidence
of a generalized aging acceleration resulting from the 1945 atomic bombing.
The validity of the concept of aging acceleration in human beingsas a late consequence of irradiation is of obvious importance in this burgeoning atomic era.
At the Atomic Bomb Casualty Commission, manydifferent age-dependent physiologic processes are being studied to
gain more information on this largest
group of heavily irradiated people.
Summary
Estimation of age by appearance, skin
elasticity and looseness, and hair graying
were studied in the irradiated and nonirradiated population of Hiroshima. No
differences in these several measurements were detected between the radiation-exposed and nonexposed components of the sample. The study provided
no support for the concept of a general,

nonspecific aging acceleration—exemplified by aging of skin and hair—as a late
radiation sequela.

36

The observations reported in this paper were
performed by the nursing service of the Atomic
Bomb Casualty Commission. We would like
to thank especially Miss Chiyoko Watanaoc,
chief nurse; Mrs. Kiyoko Minato; and Miss
Chiyo Waki.
The Atomic Bomb Casualty Commission is a
research agency of the United States National
Academy of Sciences-National Research Coun-

cil, which is working under a grant from the
U. §. Atomic Energy Commission. The commis-

sion is administered in cooperation with the
Japanese National Institute of Health of the
Ministry of Health and Welfare.
REFERENCES

1. cHeFFI, M.: Cosmetological aspects of ageing, in
A. IL. LANSING (editor): Cowdry’s Problems of Ageing,
ed. 3. Baltimore: Williams & Wilkins Co., 1952, p.

909.
2. FURTH, J., A. C. UPTON, K. W. CHRISTENBERRY, W. H.

3.

4.
5.
6.
7.

8.
9.
10.
1).

BENEDICT, and J. MOSHMAN: Somelate effects in mice
of ionizing radiation from experimental nuclear
detonation. Radiology 63:562, 1954.
Report of the Committee on Pathologic Effects of
Atomic Radiation. Publication No. 452, Section IV.
Washington: National Academy of Sciences-National
Research Council, 1956.
WARREN, s.: Longevity and causes of death from
irradiation in physicians. J.A.M.A. 162:464, 1956.
SELTSER, R., and P. E, SARTWELL: Ionizing radiation
and longevity of physicians. J.A.M.A. 166:585, 1958.
ELLINGER, F.: Medical Radiation Biology. Springfield, Il: Charles C Thomas, 1957.
CONARD, R. A., et al: Medical surveys of Marshallese
people at 5 and 6 years after exposure to fallout
radiation. Brookhaven National Laboratory Report
609 (T 179): In press.
CONARD, R. a.: An attempt to quantify some clinical
criteria of aging. In press.
TERADA, H.: Appearance of gray hair as an aging
phenomenon in Japanese. Okajima’s Folia Anatomica Japonica 28:435, 1956.
FINNEY, D. j.: Probit Analysis, ed. 2. Cambridge:
Cambridge University Press, 1952.
KIRK, £., and S$. A. KVORNING: Quantitative measurements of elastic properties of skin and subcutaneous
tissue in young and old individuals. J. Gerontol.

4:273, 1949.

12. COLE, L. J., P. CG. NOWELL, and J. Ss. ARNOLD: Late
effects of x-radiation. The influence of dose fractionation on life span, leukemia, and nephrosclerosis incidence in mice. Radiation Res. 12:173, 1960.
18. ALEXANDER, P., and D. J, CONNELL: Shortening of the
life span of mice by irradiation with x-rays and
treatment with radiomimetic chemicals. Radiation
Res. 12:38, 1960.

GERIATRICS, JANUARY 1963

Select target paragraph3