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Biology and Mecticine

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September 16, 1954

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Biology and Medicine

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COMPUTATION OF I-131 DOSE IN HUMAN THYROIDS RESULTING FROM CASTLE
FALLOUT IN U.3.

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BEST COPY AVAILABLE

Dr. Dunning has asked me to computa for you from the svailable
data the I-131 dose in human thyroids resulting from CASTLE
fallout in the U. S

I estimate the total dose to have been

less than 1,5 rep, as compared with the

sible dose per year of 15 reps (0.3 r

+ maximum permis-

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wi).

The basis of the caleulation was as follows:
Observations on: thyroid Activities

1.

LeRoy measured | human thyroids. fron Chicago antopsies by

scintillation counting,
ranged from 0.5-1.6 x

of July 12, 195h, activities
/em. dudging from half-life,

the activity was quite

tealy I~131.

hr. Dunham believes

the Jocal hospital I-131 contaminationaight possibly be the
source, rather than fallout.

2.

Harley measured 1 human thyroid from NW, Y. after digestion

and dhemical separation of I. This. technique gave high

sensitivity but Harley is not positive of 100% recovery. So
I-131 was demonstrated, and an upper limit of activity was
estimated at about 2% that observedby LeRoy.

3+

Looney and Colodzin at MMRI measured several human thyroids

from Washington by scintillation connting.

‘Their results

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kh, Hardin Jones has observed I-13] in the urine of some patients
in San Francisco, sone in other patients, His figures are
not yet available to me.
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were negative, with an upper limit of about 5 LeRoy! s

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5. Yan Middlesworth, Hardin Jones, and others measured the

activity of cattle, sheep, hog, and dog thyroiiis in June.

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On cattle and sheep their resulta (extrapolated to July 12,

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Middlesworth found hogs and dogs to contain much less

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LeRoy's data) were approximately the same as IeHoy's,

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