HEMATOLGeTe at doses well belowthe lethin range. and ineren-- ing dose resuit< mn one or donna farther ae. crease in count Lavmphocvte sepresston ay pears to have no caused reloonsthip wath aense radiation deaths. ¢) Platelet counts iave veer -tudied most extensively in dogs (26) Y wath neutroplhiles, the rapidity and maguitude of depression = 4 function of dose below the letha: ringe Viax mum depression oceurs by fe Sth or both chis with doses in the high letha. cenge. by che loth to 15th day at subletual level). Recovery begins during the 3d week. bur is not complete fv the 380th day when most stu es live been term: nated. Insufficient dita us available to ond cate the time required for 1 the mouse using spleri fomogenates, induced bacterial infections ard spoutaneous Infectious have indicated that curgea neutrophile levels is correlated with the absolute neutrophile count following whore body irradiation (15) 59 “oo, and essentiilly the same calculated exposste bar for which control hematological as were considerably different (the Lympho\te count ts pot sutable for comparison since degree of dlepression was essentially the same Po vouese ereups and the higher-dose Rongelap ETO p At the time of penk depression for euc! orferment. the neutrophile counts were esse iialiy identient in terms of absolute counts, boat ooisnmlerably different in terms of the re- 4a Approximation of Minimal Lethal Dose for Man sper ove eoutrol values Thus, some evidence oi forded that) ipsolute counts. rather than eurt> relative to control values, may be the wer sehaole index of exposure in this dose omplete recover, Considerable evidence ua. cluding studies exist. below which sueviva BSEP AA LIONS From data an dogs. t appears that surviva, is linels uiiess meutr phile counts remain below Pvc cells for 4 period of time. Platelet data on devs neaeate that animals with external purpuri nat. pdatelet counts of soe oncheation of severity of exposure can be viene freni a comparison of minimum inav dat, counts in fapanese groups in which fataltes occurred In general, a significant hoinber dv ft deaths was encountered only in in- dandy nin vhose neutroplule count fell below dn) Group 1. #2 or approximately 50 per- cent cad neutrophile counts below 2000 at some us tating the observation period, and 10 weroens had counts below 1000, By this ert terror thea. the etfective dose received by the platelet counts asa fuietion at dose rn the sa: lethal range. The response if te olatelet cout du epproxiuately an additional 60 to 100 r cee ceriuired to lower the nentrophile count by 50,000 or below Sufficient data oon arge on minus ure not vet available te quanafs tie extent rf as mum depression of © ther “he nentrophile or in the present study aa. or uch less subject fluctuation than were tae eurronhile or lyr phocyte counts preceeding For ' e o rerser s, systematic investigaten «ot che platelet oud leukocyte counts in ticee a mats toa funericn of dose in the subleth orate are imdicated It Is not possible t+ sas it present whether severity of exposure, or of radiation diame correlates better with ubsol te levels ef pernpit eral blood count. or from control woth dearee or pre-expesuse of ethane evel Sore evidence on thes pout con pe aa ned by cara paring the degree of depre stor ef the mente phile counts 1 Crror ps | nel PTE enh of Korvelap oeoole iupproached the lethal range. Poche cdoe hoes aim Cronkite and Bond, unpublished in the high sublethal close range. broese ditt enn oe applied to man, an addi- met © tf Liter would have placed the dose veo tte Jethal range. On the other hane. powecer or is eclenr from the presence data and Sores ontealy xperence with therapeutic ridia- or om eatropatle counts between P00: and Phe Gaan betes are in genernl well tolerLoe fhumat bemgs with these levels of nenGed tes show one chiniea, evidence of ness, ve cateady actives and generally doe not need eon tietie Gafrprotie therapy, Por peo de of Crronp Pare estimated to have soe Ter ois thenheted from: dose rate read-