construct am organ dose-organ respoase curve-~a graded series of cell
doses, which in principle permits us
to develop a function for
the
(fractional) number of hit cells that will respond guantally, at each value
of cell dose.
This function provides the conditional probabilities
if hic, and if a dose of a given magnitude
respond quantally.
is received, a piven cell will
Thus this function is the cell analugue of the “organ
dose-organ response” curve.
cellular end points (3).
Such curves have been derived for several
We thus have three probabilities to be evaluated,
1) that, with a given amount of exposure, a cell will be hit, 2)
that
quantally.
,, che
given exposure, of
it is
these probabilities
the fraction of
that permit the estimation,
those exposed cells
tor a
that will respond
quantally.
vel of
of interest
An example will help to clarify the above statements,
In Fig. 2 are
shown schematically three distributions of cell doses from stochastic
one
rn LLE at
cells hic
if
-
che
dose to the cell will be of a given size, and 3) that the cell will respond
the cell
e maximum
ne
that,
the
che short
arded
@
Nu/Ne
quring a
will also 4
wills with
Area =Ny/Ne FRY
of at
on
total hit, for
exposure E ~!
Cell dase, z
the
at is ©
Fig.
2nersy
yn
2
of
cell
Schematic distributions of cell doses for three levels
2
to a radiation of a given quality or mixture.
The smaller distributions in the lower
right reglon result from multiplying the larger distributions by
the HSEF shown.
cell
exact
vy
/
Note
that only the areas under the distribution and not the shape
increase with exposure.
of
ed
2
of exposure
CO
~209-
s0129ut