The
fact that D is effectively exposure and not dose also provides
into what the basic problem is when one attempts,
express
the
as
insight
is done in Fig. 1,
tv
biological respouse of cells in terms of a single variable,
i.e., as E, or the proportional parameter D.
This
is depicted in Fig. 3,
the lower panel of which shows conceptually two of the curves given in
Fig.
lL.
In the upper panel
is a three-dimensional schematic, on the
exposure-No/N, plane of which is depicted the same curve and labeled
poiats shown in the lower panel.
cell dose distributions,
1.e.,
On the Ng NpTcelt dose plane are the
the relative numbers of cells dosed, as
funetion of the cell dose, z.
the
per
las|
quar
appr
tal
z
~
cont:
o
z
cénei
Teads
Rach
CELL OOSE z
a
.
i
HIGH LET
wo
iF
z
2
=
Ps
“hit”
1D
eo
t
1
18
Low LET
The
\
from r
E(ehdeh'O)
Fig. 3 A three-dimensional schematic plot, designed to show
that any single point on a given conventional absorbed dose-response
curve doés not represent a single value of cell dose, Rather,
oe
each potot,
for any quality radiation, represents an entire
distribution of cell doses, as shown on the plane representing
Ng/Ne VS Z.
-
heac”
,
these
j
inveate
Substir
QOn-ana
idea of
Feinend
8Pplieat
Stochas,
recent (
2G 14