retarded children. "Accordingly, at the time of the September 1965 survey, the 55 people in the more heavily exposed group were started on L~thyroxine at a daily dose of 0.3 mg to all people (less than) 50 years of age and 0.2 mg to all people (more than) 50." Thus it was nearly nine years after discovery of indications of growth retardation that medication was first administered. The results, especially for one of the two boys who not only showed marked retardation, but also developed thyroid function problems, was startling. Cases nos. 3 and 5 showed "definite" spurts in growth, and there was a "remarkable change in appearance of no. 3 after thyroid hormone therapy for 6 months." (p. 40) The thirteen, fourteen and fifteen year report noted that as early as 1964 (ten year report) these two boys "had developed obvious atrophy of the thyroid gland with an almost complete loss of thyroid function... blood had low thyroxine and very high TSH levels. By this time their They showed body dysgenesis, sluggish Achilles tendon reflexes, puffy faces, and dry skin." some reason, however, this was not noted in the 1964 report; (p. 25) in fact, For that report states in a photo caption that ''The retarded boy shows no evidence of hyperthyroidism or skeletal disease clinically, other than markedly delayed osseous maturation. (p. 24) [emphasis added] The Committee finds itself puzzled about how, during the 1964 survey, the boy is noted as not having hyperthyroidism and yet in a later report was supposed to have been at that time in a hypothyroid condition. The implications of these findings and treatment regarding growth and development will be discussed in the firal section of the report. 113 1014720