09-21-1994 12:11 S162€25311 P. 003 BNL-MED. DEPT. Mr. Chairman, Congresamen and Observers: I have been asked to summarize the early effects of sxposure of|aninals amd man to external radiotion with particular reference to the effects of fallout radiation on the Marshallese, the Los Alamos accident amd radium, I have been asked to comment on the beta burns in the Marshallese and of beta burns. addition I qther examples Since my personal experience is limited to the Mar lese and ar imal experimentation I shall limit myself to these and supply reference material for the others. It is quite impossible to cover all of this material in a reaso ble period of time so I shall concentrate upon the effects of exposure to extersht radiation on animals and man with a clinical description of the syndrome of radh ation sickness as a funetion of dose of radiation and highlight the discussion ith illus- trative material collected in the study of the Marshallese (1). My prepared statement includes numerous references and further :n terial that time will not permit discussion of at length here. Radiation syndromes vary as a function of the type of exposure, the time after exposure to radiation. he dose and In general radiation injuries ¢ an be divided into three. gerieral classes: os a) "The: syndromes of whole body radiation injury produced by per etrating lonizing radiation which are dose and time dependent. b) «Superficial radiation burns produced by soft radiations (be and lov energy x or gamma radiations). e) Radiation injury produced by the deposition of radionuclides vithin the body. In the latter casa the clinical picture varies with the site and amounf Each of the above is associated with an early phase in which acut and signs may be observed, and a late phase in which chronic changes o tions such as cancer may be observed. of deposition. symptoms manifesta= I wish to emphasize also that the degree

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