In the following descriptions and cofipacisoasagthe data, fludings in the exposed groups
are usually expressed in terms of per cent of the appropriate control group. To should be nated,
however, that in observational studies of this kind, unknown factors could possibly aecount for
4.4
HEMATOLOGICAL FINDINGS, GENERAL
Total jeukocyte, neutrophile, lymphocyte, monocyte, platelet and eosinophile counts for the
several exposure groups are given by day and by age in Tables 4.2 to 4.5, The meantotal white
t
i
y.
.
{
.
;
ao
a function of time and aye are shown aiso in Figs. 4.1 to 4.8. The cumulative distribution
curves for the various exposure groups, using the average of counts obtained over the period
of maximum depression (days 39 to 51 for leukocytes, days 26 to 30 for platelets) are shown in
Figs. 4.9 to 4.11.* In the figures emphasis is placed on the individual blood elements rather
than on the total leukocyte count, since the component elements have distinct and different
time trends after irradiation.
Table 4.2.
RONGELAP GROUP MEAN BLOOD COUNTS BY DAY ANDBY AGE
- W.B.C,
p.E. Day
3
(« 10%
<3
3
Neutrophiles
{~ 10 3
Lymphocytes
Platelets
3
_ & to
7
+5
~5
>5
<5
o5
9.0
8.2
6.4
4.7
1.8
2.2
o to
<15
7
4.9
6.2
10
6.6
7.1
3.5
4.5
2.6
2.1
12
§.9
6.3
3.5
3.9
2.1
1.7
15
5.9
6.5
4.2
4.1
2.4
1.9
26.1
Li
6.7
7.2
3.4
4.7
2.4
2.1
23.0
22
7.0
7.4
4.5
6.0
2.6
2.4
16.2
ati
h.7
Gl
30°
93.9
2.3
1H
12.6
Monocytes
; — (> 10 Ty)
+15
27.5
22.1
Euosinophiles
2
{x wer
«5
95
-5
>§
0.8
0.3
0.1
0.7
2.9
1.7
1.6)
1.6
4.2
5.4
LY
1.9
19.8
30°
2.3
VebooList
19.6
2.7
=#41.7
4.5
1,6
14.7
1Y
2.4)
Za
18
fOL.0
LY
1.6
Lod.
0
7.45
7.8
4.0
6.3
4.20
2.1
3.90
LI.
Lo
OY
+40
2.2
at
Oy
2
10
Ub
4.2
2.0
17.9)
14,6
7
lob
2.4
2.2
ay
nf
OG
3b
cb
2.6
2.0
23.4)
21.6
Ob
OLY
flee
10
43
ff
4.2
2.00
2a
2.9
2.0
26.0)
Zi.K
1.1
oft
1.4
OQ.
5.0
Gt
2.6
3.9
a1
2.4
268.4
20.6
1.0
ba
Ll
Oo
St
47
‘
6.7
5.6
241°
35
3.4
2.1
24.2
1H.2
2.9
1.6
0.8
0.7
56
7.0
G0
0
3.5
3.7
2.4
1.7
1.2
Gu
7.7
GL
39
3.6
3.7
2.9
Oxo
U9
Th
7.6
6.5
3.8
4.0
J.3°
2.2
2t.8
74
Majuro
Controls
IG.1
28.1
13.2
9.7
4,8
4.8-:
. aeSEs
-.
halk
.
4
2.0
mS
a
.
O.G
1.9
9.5
4.7
_
21,1
eS 30.8
t ah thi:
0.3
a.4
°
2.0
B .
*
~
i
+
count, neutrophile, lymphocyte and platelet counts at the times of peak depression (time over
which counts were consistently the lowest) are shown in Tables 4.6 and 4.7 (pp 78 and 79) for
each individual in the Rongelap and Ailinginae groups, respectively. Hematological findings as
Lee
*In the Utirik group the cumulative distributioncurve for platelet counts only is presented
ere
since hematologicaldeterminations in this group were not made during the 39 to 51 day period,
used for leukocyte comparisons amongthe other groups.
4
\
sly e
aw
hot necessary to specify the functional aistribution of the variate under study) were used 28-8
The advantages of nonparamictric methods have been summarized,
sac tptye
Rae
meisures were taken to select a comparable control group. Tnaddiftten, it was not possible ta
obtain more than a single blood sample on each control individual, For these reasons, stiatiatl cal tests of siguificance were applied mainly to time changes within an exposure group, and not
to differences between control and exposure ~roups. For the purpose of detecting significant
changes in the hematological pattern, nenparametric tests (i.e., studistical tests for which it is
rumenpyr ey me
part of the differenecs noted between the control and exposure groups even (hough all possible