38

phosphatase staining of neutrophils showeda generally normal distribution of positive cells, as in
the previous year. Basophil counts of 4000 cells
showednoincrease in levels above the normal per-

centage in anysubjects, either exposed or unexposed, in the 1959 and 1960 surveys, except for
one 6-year-old exposed boy ( #3).* The mean
percent basophil count (counting 4000 white cells)
for the exposed Rongelap group was 0.42% in
1959 and 0.93% in 1960; in the Ailingnae group,
0.29% in 1959 and 0.80% in 1960. Basophil counts
on the unexposed groupare not yet complete for
1959. The individual values for alkaline phosphatase and basophil counts are presented in
Appendix 5.

ComplementFixation Tests

The results of the complementfixation tests are
shown in Table 23. In discussing these results Dr.
R. J. Heubner madethefollowing comments:
“I suppose the most interesting thing is that
there is evidence of infection with almost all the
groupsofviruses that wetested for. It is important
to point out that complement-fixing antibodies are
generally less persistent than are hemagglutination inhibition and neutralizing antibodies. Therefore, the high levels of adenovirus and HA | complement-fixing antibodiesreflect either recent infection or multiple infections with various members of the parainfluenza family of viruses. The
low levels obtained for other agents, such as influenza A,influenza B, HA 2, CA, mumps, LGV,
and fever mayreflect low levels of infection with

these agents, but more likely might reflect the fact

- that such agents have not been prevalent in recent
years. Thus, one might conclude from the data
that the Asian influenzavirus has not yet seriously
involved the Marshall Island populations, or else,

of course, that the complement-fixing antibody
produced bythe Asian influenza hasnotpersisted.
“T would rather suspect from the age distribution that Asian influenza still has not reached
these people, and that one might look forward to
see if they are involved at some future date. Simlarly, the age distribution of influenza B antibodies suggests that it has not occurred for at least
6 to 10 years. The absence of HA 2 antibodiessuggests that the virus has not been prevalentin re-

*In 1959 his basophil count was 2.1%, WBC 8600, and alkaline phosphatase negativecells 79%. In 1960 his basophil count

a)

C3

om

cr)

Cr

was 3%, WBC 6100, and alkaline phosphatase negative cells
70%. No abnormal forms wereseen.

cent years. However, the total absence of antibodies even in persons over 40 suggests the possibility that it has not occurredin this population
at all, but the first interpretation is equally good.
The same comments would refer to the CA virus
or parainfluenza 2, but here the morelikely interpretationis that the virus has not been present in

the recent past, but the presence of antibodies may
suggest that it had been present 16 or more years

earlier. Since there is some overlap in antigens and
antibodies between mumpsandthe parainfluenza
group, the CA reactions and/or the mumpsreactions could conceivably merely reflect infections
with other membersof the parainfluenza group.

“Tt would be interesting to find out to what extent the psittacosis group and fever represent a
threat to this population, and of course in the
birds and domestic animals as well.”
Dr. Heubner’s forecast of Asian influenza in the
Marshall Islands from the Rongelap datais interesting in that an epidemic of serious proportions
did occur at Kwajalein Atoll in January 1960 resulting in significant mortality.

The average antibodytiters for the different age
groups in the exposed people were, in nearlyall

cases, lower than in the corresponding unexposed
age groups. It is not known whetherthisis a significant finding; further studies will be done to
determinethis. At three years after exposure, the
primary responseto tetanus antitoxin averaged

slightly less in the exposed people than in the un-

exposed.* However, because of the small numbers

of people studied, this finding could not be considered significant.
Sodium and Potassium Levels, 1959

Potassium intake appeared to approximatethatof

Americans, namely, 240 to 100 mEq/day. Salt

intake varied widelyas judged byurine excretion,
ranging from 2 to 18 g/day. Therelatively high
salt consumption of some individuals is undoubtedly related to the irregular consumption of

canned C rations, to which 2% NaCl is added

routinely during preparation. The median intake
of salt appeared to approximate that of male employees at Brookhaven National Laboratory,
namely, 10 g/day. This undoubtedlyrepresents

an increase over the intake in earlier years when
only native foods were eaten. It will be of interest
to note whether the incidence of hypertension also

will begin to increase. At present the prevalence
of hypertension (B.P. greater than 140/90)is 9.2%

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