-15- PRIVACY ACT MATERIAL RE MOVED Cases With Hypothyroidism The development of hypothyroidism in the two boys(with the greatest retardation in growth, as evidenced by PBI values dropping to below 2 ugmZ, the nonpalpable thyroids, and the Achilles reflex with sluggish return, Suggests defective thyroid funetion in the etiology of the retarded children, even though PBI levels have remained in the normal range in the other children in the group, However, two of the boys, cases __ and , with thyroid nodules were in the group that showed retardation of growth and development. Protein-Bound Iodine Determinations Protein-bound iodine determinations were carried out on 31 exposed and 19 unexposed Rongelap people, No significant differences were noted between the exposed and unexposed groups, with American levels, Again, however, the values were high compared PBI levels in ugm% were: Marshallese exposed, 7,6 (4.1-11,9); Marshallese controls, 7,0 (3.9-10,7); medical team (Americans), 4.9 (2.5-6.9). An evaluation of the elevated Marshallese PBI levels over the past eight years as well as) >*y uptake studies of the thyroid is being published, (15) Elevated PBI's were found in 20-40% of the Marshallese people. None showed evidence of hyperthyroidism, throughout the population. The elevation is seen generally Column chromotography of serum todine has revealed | high iodoprotein levels in the Marshallese which appear to at least partly account for the elevation in the serum PBL's, 132, Uptake and Excretion Studies 1325 uptake and excretion studies were done on 12 people in the exposed and 9 in the unexposed population, The rate of thyroid uptake and the rate of urinary excretion were both depressed to about one ~half normal, was noted in both the exposed and the unexposed people. 0 0 0 V4 v 1 This depression The explanation PRIVACY ACT MATERIAL REMOVED

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