132 BUSTAD: DASA 2019-2 Yes. CONARD: Are you intimating that in the case of the Marshallese their gamma dose was probably significantly higher than we have calculated? BUSTAD: I'm only trying to generate ways these children may have had more radiation than wae estimated. In addition to you, I've talked to many other people who have had association with it and they will admit that maybe it could have been something over 200 (quite a bit over 200 possibly), and then we have to admit that 1400 rad as a maximum may not be a true maximum depending on what the experience of these children was during this period. ['m also worried a bit about the short-lived isotopes which can really contribute very heavily to a radiation dose, and I'm speaking of iodine 135 and 133. The fact ie they may contribute up to half or more, especially in the early period. MILLER: You keep speaking of 30,000 r to ablate the thyroid in an adult; how much is required in an animal one-month old? BUSTAD: I feel that—and this is partially intuition— it's possible to see hypothyroidism. If you permit me to choose any animal and choose a certain desage regimen, [ could produce it with maybe 5000 or 6000 rad in an animal that's very young providing you wait the ten years or so that Dr. Dunhamnientioned earlier. MILLER: There is a need to make a study in animals that duplicates the experience of these children. , BUSTAD: Well, I've discussed this with Dr. Dunham some time ago and some of this is under way. DUNHAM: I think the point is well taken that it is a combina.ion of internal and external. BUSTAD: DUNHAM: BUSTAD: That's right. And in the other data, it's either one or the other. That's right. And I feel strongly about this. BRUES: Ablation of the thyroid is a different matter as regards the production of adenomas. You have to leave some tissue but remove enough so that the pituitary sees a tiyroid deficiency and stimulates