NATIONAL INSTITUTES OF HEALTH CLINICAL STAFF Several points of interest are revealed by these data. The two subjects with severe growth retardation (Cases 3 and 5) had very low thyroxine iodine levels, little or no accumulation of 18*I-by the thyroid, and very high levels of TSH in blood. The TABLE 9. Case Sex latter finding indicates that the growth retardation was due to primary thyroid failure and not to pituitary failure, which was suspected before the appearance of clear-cut thyroid findings. Several of the patients who had had partial thyroidectomy (Cases Thyroid Studies in Subjects with Thyroid Abnormality* Thyroid Abnormality Age 3 M Atrophy vr 13 5 M Atrophy 13 17 F 15 21 F 69 F 2 M Nodular goiter Nodular goiter Nodular goiter ’ Nodular 20 M 72 F Nodular goiter Nodular 42 F 61 F 54 M 19 M 36 M 33 F 65 F 59 F 40 M 64 F ” goiter goiter Taternal Medicis Nodular goiter Nodular goiter Nodular goiter Nodular goiter Nodular goiter Nodular goiter Nodular goiter Solitary nodule Solitary nodule Carcinoma Year Tested Neck ?##J Each 4 Hrf PreTSH PostTSH PBI T,lI 13 1965 1966 1965 1966 1964 1966§ 1964 1966§ 1965§ 1966§ 1965 6.5 (29) (23) ug/100 ml 1.4 0.8 3.2 1.0 1.9 0.8 3.1 1.8 6.8 18 <0.5 8.1 13 <0.5 7.1 5.7 1.7 7.9 4,2 19 1965 (31) (31) 6.5 15 16 % of dose Serum Iodine 1966§ 5 8 18 5.2 2.6 4.2 18 1965 15 1966 (15) (24) 5.7 4.6 20 1966 12¢ (10) (24) 7.9 4.9 13 1965 1966 1966§ 19 8.3 5.0 3.9 4.3 3.3 17 19 13 13 35 40 31 1965 1966 1965 1966 1965 1966 1965 1966 1965 1965 1966§ Serum TSHt mug/ml >120 159 119 248 372 440 125 9.6 26.6 5.3 (16) (24) 17 (9) (14) 7|| (20) (38) (19) (28) 4.1 4.2 7.0 5.9 4.9 3.1 8.2 8.6 10.3 8.6 4,9 4.3 3.8 2.1 1.9 5.3 4.8 <17 <3 <17 <17 <17 7.3 197 6.6 23.5 3.4 2.0 * TSH = thyroid-stimulating hormone, PBI = protein-bound iodine, T,I = thyroxine iodine. } Values in parentheses are “corrected” counts obtained at Brookhaven National Laboratory (see text). The others are not corrected for extrathyroid counts. t¢ Assays in 1965 could not detect levels below 3 mug/ml. Seven unexposed children in the same age group had <3 mug/ml. Assays in 1966 could not detect levels below 17 mug/ml. Three exposed children without thyroid disease (Cases 6, 8, 32) had <17 myug/ml. Two children exposed in utero (Cases 84, 86) and two unexposed children had <17 mug/ml. § After partial thyroidectomy (for Case 64, total thyroidectomy). | While taking thyroxine. tasaliihtineltbiel idl 1234