74 area in the child. A Does this give a significantly higher dose to those areas so that you may have a different set of standards or think of it as different for a child than an adult? DR. BUGHER: think so. I If you are asking personally, I don't think in considering permissible dose, we have oftentimes thought of the bone marrow being much more static than it is, rather than regarding it as essentially fluid The probability is that the 10 regularities of concentration are not as important as 11 we have assumed in computation. 12 gets in the picture for irregularities, and nonuniformdistri: 18 bution of the material with respect to bone marrow. 14 certainly bone marrow cell structure is a highly mobile one 15 in terms of comparative bone sells, 16 quite possible that we over-emphasized the fact of non- 17 uniformity, 18 Usually a factor of five for example; t Washington, D. C Alderson Reporting Company tissue of a slow flow rate. But so it is and such experiments as we have had in regard to skin activities wuld seem to indicate that the non- 19 uniform sitwtion is actually less of a problem than the 20 uniform distribution of the same amount of material. 21 LT. SHULMAN: Is there sufficient data to know whether the local bone dose in children could be suspected of giving abnormal growth? ARC Do the levels they probably have come close to the levels that 26 - Pi “ot ARCHY: =3 development, such as in the chickens? That is abnormal 1 a te Depart© vetl it storianh 8 do give abnormal 25