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period between exposure and nodule discovery varied only between 10
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and 13 years it may be argued that development of thyroid nodules was
'
independent of these stresses.
On th . other hand it is noteworthy chat
4
all of the women who developed malignant thyroid lesions had multiple woe
pregnancies prior to the appearance of such neoplasms.
The development of thyroid nodules in the Marshallese showed only
-
This is .
_@ slight preponderance in favor of the females (1.3 to 1.0).
similar to the near equal sex ration reported by Toyooka et al,12 for
thyroid nodules developing in persons irradiated over the neck region —
in infancy.
However, in the case of ‘carcinoma of the thyroid the expected "0
. female preponderance occurred”.
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The insidious-development of growth retardation in some of the_
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.
‘
op
oat
Marshallese children before clinical evidence of thyroid abnormality or
' deficiency was recognized demonstrates the apparent sensitivity of growth es
and developmental processes to borderline or subclinical thyroid deficiency... °
All possible steps are ‘being taken so that the children will adhere to oo
_the present thyroid treatment schedule so that thye will achieve satisfactory .°
growth and maturation. ~
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Careful medical surveillance of these exposed people including those ° ..
4
.
To
on Utirik will be essential in future years.: The latent period for the °
'development of cancer was 7 years in one case and 14 and 15 years in the other two.
The fact that there may be a longer latent period for the |
induction of malignant change is borne out by a report by Goolden who
.
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.
.
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noted the development of thyroid cancer 40 years after radiation exposure!8,
It may be that we are just reaching the critical period in the post-radiation _
|
observations.
.
*
DOE ARCHIVES © *
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