EFFECTS OF WHOLE: BODY IRRADIATION ON MARROW
475
Fig. 2.—“Mitotically connected abnormalities” in myelocytic and lymphocytic
“Giant cells,”cells of human bone marrow during the first days after exposure.
mono- or binucleated: A-G; N, O; binucleated cells with (D) or without internuclear
bridges: C-G; aberrant chromosome in mitosis: H; karyomeres in interphase cells:
G, I-R.
In myelocytic cells, M. C. Abn. were seen and recorded from the study of
500 erythroblasts. For the present study, abnormal mitotic figures and interphase cells were pooled. Examples of such cytologic abnormalities of myelocytic cells are given in figure 2. In the smears of persons used for comparison,
there were no abnormal mitoses as defined in this study and no myelocytic
cells with karyomeres or “giant cells.” A very few binucleated myelocytic cells
were seen in the course of counting 10,000 erythroblasts. The frequency of
myelocytic M. C. Abn. was 0.03 and 0.02 per cent per 100 erythroblasts respectively in marrow smears of two of the normal persons used as comparisons
in which 3000 and 4000 erythroblasts were counted. The changes in the fre-