Hugh S. Prat M.D. October 7, 1,7 Page eight 2. EXPERIMENTAL DESIGN PROBLEMS After the initial crisis of the acute radiation effects had subsided, was a long-term prospective study research protocol devised, based upon the then known, long and short term biologic effects of the specific isotopes identi- fied in the exposed area? Was there a pre-selected data base for the study groups, irradiated and controls? Was adequate data available on the unique biochemical profile of the Micronesians, to determine if the values found in the study represented a significant deviation; if not, when and how was the normative data derived Has a Marshall Island Study methodology been formulated (in a written format) to: 1) describe and coordinate the procedures and methods of all examinations carried out on the group 2) provide standardized data for cooperative studies 3) serve as a guide for future evaluation 4) display the methodology employed in a fashion which lends itself to study by critical reviewers 5) suggest by retrospective analysis, necessary modification