42
Table 30
Distribution of Haptoglobin Types in Micronesians From Rongelap Atoil
Type 1-1
Group
All Rongelap
Selected* Rongelap
No. in
Observed
group
%
No,
176
124
33.5
33.1
59
41
Type 2-2
Expected,
Observed
No.
%
59
~
18.2
15.3
No.
Type 2-1
Expected,
Observed
No.
%
No.
31.5
47.2
30.0
83
62
O and rare types,
Expected,
No.
85.5
-
Observed
—————_—___
%
No.
.
1.6
2
2
*Family groups include only one child (see text).
B-Amino-iso-butyric Acid (BAIB) Levels. Figure
46 showsthe frequency distribution of BAIB excretion for the Rongelapese and that of a New
York City white population for comparison. The
two distributions are essentially complementary to
io
61S)
(2D
OS
MARSHALL ISLANDERS {RONGELAP)
N7168
SI
haptoglobin at one time, but have sufficient haptoglobin to permit typing at anothertime. (In this
case, the interval was 2 years.) Examination of the
ahaptoglobinemic individuals gave nosignificant
findings. With ~% of the Rongelap population
sampled,all the ahaptoglobinemic individuals fell
into one family grouping. This did not help to
elucidate the genetic pattern, except to makeit
appear unlikely that the Hp’allele, if such exists,
is not at the samelocus as the Hp' and Hp’alleles.
Oneofthe sibs of an ahaptoglobinemic was a type
2-1.
OMERICAN WHITES
SS
remote from it.
Ic is clear from the Micronesian studies that, at
least in some cases, an individual may have no
BAIB excretion values for the two (exposed, 2.07 =
SS
quencies obtained from a small sample. This is
particularly true when studving societies made up
of small isolated or semi-isolated groups which
compartmentalize the breeding community. Thus,
the Rongelapese appearto havea fairly highfrequencyof type 1-1, consistent with the general
(though not exclusive) rule that in Europe- Africa
and America the frequencyof type 1-1 is higher in
populationsliving near the equator than in those
unexposed groups showsalmost identical mean
q
ANN
SS SSS Rees
SS
trapolating to an entire population the genefre-
ny
\
The Micronesian sera studied wereall transferrin type CC, which is the common European
type.
Considerable caution must be exercised in ex-
modality with the antimodein the neighborhood
of 1.75. With this point used as the division between high and low excretors, it is estimated that
nearly 90% of the Rongelapese are high excretors.
A breakdownofthis population into exposed and
FREQUENCY (PERCENT)
in them.
one another, and, if superimposed, exhibit bi-
FREQUENCY (PERCENT)
werevisible; two of these were very faint 2-2’s, but
the fastest-moving haptoglobin band was not seen
eie
y
7 tinW
Figure 46. Frequency distributions of urinary excretion
rates of B-amino-iso-butyric acid of Marshall Islanders
(Rongelap) and U.S. whites.