leg in normal mice and mica and the mice rad iucrements 24 hours apart. after irradiation and Animals All itGu rad anisals dieu by the survivors had a very the “iltn cay low CFU-S content oF about 2 receiving a 25. tua cose at 24 hour intervals tad an equal depression of their CFU-S, isllowed by an exponentis te perc leg. in tout 159 siugle douse or 1009 rad it a 1C0u rad receiving ldv, VGO, or 30 ras receiving a single Gose of recovery is near normal levels by 3U days after exposure. Geath in the irradiated animal living primarily in in the LD, ranse. the ygastroiutestinal ' ¢ ul c r 1 ib a u 5 ts we u“ Bacterial infection has long teen estauvl ow Therapy of Whole Body Radiation Injury The commensal organiss tract are the tistal orgzaisms tt. xill the animal that is irradiatec in the LDsq range (li, 26, 33-49). The use ot antibiotics as an effective treatment was first shown by tiiler et al. (41) with the administration of streptumycin in mice. germ-free aninals have teen studies (42, 43) ane In acdite these auniwals live lecger. dying from hemorrhage anc anemia rather than infection in the absence bacteria. The effectiveness lethal dose level since of entibiotics faulis oft as one to marrow cegeneration ensues. tne antibiotics being Taketa (464) has tne 1 rat. ri 4 in (228Se Sluuie3s microorganisms play a prominent riie death in the rat, and iautensively stucied the .t vas ciearly in the genesis this was mor:ified by of acute intestinal inte snmem tuert Latsstine It is a beneficial ioc ba. effect not Limited to rodents. 7:3s have been treated with success fluid replaceient, traasfusion. (47). In the letter study, combined with successive antiblotics. organisms of bloua in view of Witn «= ar-natic improvement in mortality .as obtained by Coulter et al. (45), and Allen et al. osiss the use of ancinistic: and intensive administration of water and electrulytes. antibiotics, lv: used belore tone therapy against tre actuUie of water-electrolytes and autidiotic Geain the sone marcrcw regeneratisa is delayed =o9 ling tmet bacteria develop resistance radiation nears of Hanmond (45°, trausrusions were che fact that conmeraal the intestine are frequently culcuread from tne slooc of tne fatally trradfated mouse, webster (48) tested the effect of oral aeome rica in siunai fror 769 rad sooTe 4k through 2500 rac. rats. Gracea Neonvein teant proiensation of the mein survical tio. oc: be treatment resulted used body x-irradiation of a sadiation were from snole » coses of the nortality rh therapy upon