te% and GO, is approximately 00 rac.
tor ranis

in

the vicinity of
,

irradiation nave

levels

of about 27
Prubable

the

severe

Fact

(26)

one would
rr

Fresh whole blooc ane 9
‘

the survivel rate.

(27)

therapeutic tctal

Urrects of

that antibiotics

et al.

This

rac.

cf

increase

therapy.

rematepuretic cepression occurring at cose

Cn clinical grounds,
antibiotics,

that patients given

the ebsence

incrgs:e

think that the combined use of

alten

een

o

dody

is bolsterea by

369 rad micline in

of any efrective

ow

estimate

Utraura,

can wake a first Suess

t

a

the Lie,

oe
et
uv

thas

Thus, one

trunsiZusions when neeteu, wouls

learly snrown by Miller ez al

the survival rate of

irraciated mice.

obtained no markec benefit from antibiotic and

trerapy in their stucies.

Furth

transfusion

nN
Cvtsequent
stuaies by Sorenson et al. (25) ane

Perman et al. (29) bave clearly shown that one can consistently reduce
rortality from a near

This enables

uncomplicated whole

one

to

clatelet-rich plasna when
“4
a

be

needed.

supplemented by

the

successive antictiotics anc whole bisod

No

transfusioms

high dosage of

Ua

combined use of

LOG fatal cose to about 1b mortality in dogs by

it

rad cells aze not

the sisnoidal dose mortality curve

of

Doay radiation injury to a much steeper one snittin

the LDsy from approximately 3U9 raq in the aog to a little over 40% rac.
The 5% mortality is shifted frum reuyaly 250 tac to about 460 rad rtesultin,
in

A

Tag

,

neariv

licrle

although

gucid

wae ei Aa

beneric

a toaeman tele

is

the survival

cvartality

curve.

Alter cuscs

ia

BASSso

UL

oe

observec unc Wita greater coses nu animals sutvive,
time is moderately increased.

Thus, one can

anticipate that antadiotics, Lrvvd transftusiuns ana platelet transfusions
would benefit muman
The

relatiouship

in dozgs ard man
ef

beings.

further points up

antibiotics,

were exposed
Pp

uf rortality

In Figure 2

to &
gamta

te

the

im the granulocyte count

impurtant role of

is shown

The granulocyte curve at

avout 607

infection anc value

the sranulocyte cvunt in dogs

radiation from a nuclear bemb and

with percent mortality.
that were exposed

to derressica

rad midline dose.

the correlation

the far
“Note

that

left is in doxs

that

the bl<od

counts Geclined and all animals were cead by the seventh day cf exzosute.
At autopsy

infection was clearly

the major cause of

death.

In

the next

Curve the mortality was also 1707, with a slower decline in granulocyte
longer survival tine.
“Jd

count along witn a

Sao tkwss

at autupsy the major cuuce of

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