Certvation cf tre HSE The decivation of the USEF ts Jeseribed la decafll elsewhere (- 3 Tne baste tuput fatornattion consists of quite accurately Jecernined coll cesponse data, for a secies of In adauiction, qualictres. radfaclons covering a wide Span of {ct is necessisy to have quite accurately deteraised alerscedusinetrte data, hits ana be Seem that will oravidge both the nit-sloe distributhlons. in Fisure 5. Le regions of overlap, fudepeacent of is size Jistciductian of independent individual hit sices. process, to assume that, hits of a given size wtll have tne hie overlap provide These ¢istrlhucilonus overlaz, rceasouable the differenc distributions can the ausber3s of the same effectiveress, oclein, Tle= eftecticanes: of than te obtained, ana then possible, ai: 23n in ang Close i. tne the resioas of fafornation on the effectiveness of It is cell tre by an icerative ceconveolstion. to arrive ultimately at an HSEF that wost accurately f1ts tre {nput cata. This derivation ts purely empirical, i.g., tadependent of assumptions or tne radlattons. if not all of available radloblological actloa assumptions about mechanisms, e.9., be responsible roc some or all of the HSiF, om is coupletely theorles In respect to molecular of others subcellular mechanisms of action of derivin.: it In other words, 7935C theories, begin with that single or double strand >drea.s ‘as the cell transformations observad., the other hand, only otserved cuantal reSponses are used. Anomalies in the Present System shown in Fig. 1, in the sec of typical cell “dose cesponse™ curv ’ i Several anomalies can be poinced out immediately. For instance, althcceh the response is of individual cells, the “dose” is to the entire orgsn. {is taken to be axiomatic that the scitulus to an Ladividual, be it it a sell of an organ, must he measured at the same level as the inittal blological response. Although the effective agent is purported to be energy, mrlad “dos. response” curves are deawn for that same agent. Lithiun fons, the same particle but with different energies resuits ia mackeily different curve slopes. be added energies, to the set, until the In fact, more and more curves can readily simply by using different sarticles of differen: rcoughly trlangulac area cepresented by the curves 13 13 Soc tbe Also, as seen vith -