Certvation cf tre HSE
The
decivation
of
the
USEF
ts
Jeseribed
la decafll
elsewhere
(- 3
Tne
baste tuput fatornattion consists of quite accurately Jecernined coll
cesponse data,
for a secies of
In adauiction,
qualictres.
radfaclons covering a wide Span of
{ct is necessisy to have quite accurately
deteraised alerscedusinetrte data,
hits ana
be Seem
that will oravidge both
the nit-sloe distributhlons.
in Fisure
5.
Le
regions of overlap,
fudepeacent of
is
size Jistciductian of
independent
individual hit sices.
process,
to assume that,
hits of a given size wtll have
tne hie
overlap provide
These ¢istrlhucilonus overlaz,
rceasouable
the differenc distributions can
the ausber3s of
the same effectiveress,
oclein,
Tle= eftecticanes: of
than te obtained, ana
then possible,
ai: 23n
in ang Close i. tne
the resioas of
fafornation on the effectiveness of
It is
cell
tre
by an icerative ceconveolstion.
to arrive ultimately at an HSEF that wost accurately f1ts
tre
{nput cata.
This derivation
ts
purely empirical, i.g.,
tadependent of assumptions or
tne radlattons.
if not all of available radloblological actloa
assumptions about mechanisms, e.9.,
be responsible roc some or all of
the HSiF,
om
is coupletely
theorles In respect to molecular of others
subcellular mechanisms of action of
derivin.:
it
In other words, 7935C
theories, begin with
that single or double strand
>drea.s ‘as
the cell transformations observad.,
the other hand, only otserved cuantal reSponses are
used.
Anomalies in the Present System
shown
in Fig.
1,
in
the sec of
typical cell “dose cesponse™ curv ’
i
Several anomalies
can be poinced out immediately.
For instance,
althcceh
the response is of individual cells, the “dose” is to the entire orgsn.
{is
taken to be axiomatic that the scitulus
to an Ladividual, be
it
it a sell
of an organ, must he measured at the same level as the inittal blological
response.
Although the effective agent is purported to be energy, mrlad
“dos. response” curves are deawn for that same agent.
Lithiun fons,
the same particle but with different energies resuits ia
mackeily different curve slopes.
be added
energies,
to the set,
until
the
In fact, more and more curves can readily
simply by using different sarticles of differen:
rcoughly trlangulac area cepresented by the curves 13
13
Soc tbe
Also, as seen vith -