Although tc is also useful to distinguisa between sctochasticaliy
delivered as opposed
to planned doses,
substantive requirement.
this fs
to avolu confuston and not a
In othee words, all else being equal, an crvantsna
has no physfoloxical means of
deterutaing woether a glven asent trainst
has occucred stochastically or by blan.
It
fs only
Inferososimetric
because of
methods
Gose approach can te
the above-oucliney capanilities ot
that
tae
realized.
enormous
The
of
the
deposition.
the muaber of hits and
rad‘ation particle
“object-orientas” quantities, on whicu
it is unnecessary
the
not only in
most
“pure”
that
of
radiations,
the fluences and energles of
fielus,
to
che extent and severity of effect
In other weeds,
determine
the difference
che
flela
strength
permitting measurenents
for
of
In zixeg
cto define adequately these variables.
to measure
to be made at tne
these quantities.
Nicrodosimetry in
tnese quuntittes.
is
thet,
tiie of stochastic eveuts,
in
they
Iven though ict is usually not
to designate which living cell
particular hit stze
accurately
it 13 possible
to stace
that were hit at any given value of z,
for
Thus one has essentially ali che information that one
ina pharmacology and toxtcclogy,
env eciven dose level
is hit, or to attribute an;
to any particular ceil,
the relative numbers
any given exposure.
in wiich the number of individuals at
is known prectsely, and from which the (fractional)
‘uantal responders can be determined.
LU
50g 1u54
test:s
turn the abstract risk of being dosed and of cell doses into
concrete valuzs
nuc.s o of
in
tyres of particles.
The companion advantave of uslnz microdosimetric methods
has
the Ileld
they are too remote from the biological effecr tu ‘ake
peinciple obviates any requirement
rossiule
ia
The large advantave of this
them useful for quantitative prediction purposes.
in effect
se
the
ts quite difficult saractically, even for
it is essenctialiy imposstble
Even if defined,
co
the hilt sizes are completely
to know anything about tne nature of
ict usually
elsvent
~
in whieh the dfological material {ts exposed.
lies
the
cesponsldle for the given enaeray
resulting fron cadiation exposure depends airectly.
principle,
ustit.
instrument is “completely blinu”
tyoe oc enersy of
Thus
advantazes