could strenytnhen substunttally
equitable resolution of
the value of
legal claims
speeitte earlier exposure
this appruacih ia insuring
tnvolving an allepatiun that a
is causally related
Co 4a particular, extant
cancer.
“ote
that HSEF’s
for macro secidents,
in which stochastic energy
transfer
referced
tu operationally.
response
that may result can be
concept mor
Similarly,
ceadily observed, so that neither a dose
time of exposure must
Since
be observed promptly.
Thus
that early
aA complete approach to riSk asSe3Sment at the
the HSEF for cells.
the HScF replaces LET concestually,
this may
be ot significance
the detatled significance of “track structure” with
radiations of difference “qualicy”.
Much of what nas been ascribed
track structure differences, my well be simply due
to the cells.
it is only for
such as cancer or heritable defects,
then involve
those interested in
dose
cisx evaiualisza.
quantal responses of cells, can in most laboracory exneriments
observations ace precluded.
has
is because a quantal
sase“response culallonsaips are reyguirea foc
severely delayed responses,
and
Ls sirmlated, are aot uses or even
The vooviuves reason
using “single cell systems”,
to
altuoeh vdta.sed im experictents
With most,
to LET
to a difference in
particularly stochastic arent transfers,
1t
been more or less generally accepted that a larger dose will be ora
effective per unit dose
Chan a smaller one, apparently with little or xu
necessary recduftrement setng perceived
The proposed approach has
used
t3 investigate wh.
relevance
ita the “extrapolaticn” currenily
to estimate cancer risk from low-LET radiation at very low “doses”.
Clearly, one is not extrapolating hizh- to low doses of
Rather,
one is extrapolating to
the lower reaches of a curve representing
the probability of an expressed cancer, as a function of
malignantly
transformed cells in
the azent ener-y.
the sumber of
the organ or organs of interest.
The interpretation of a “linear, non-threshold” curve (for exposure
and not dose) also changes.
exposure,
is true
- lethal.
What is meant is
there can be stochastic interaction with health consequences.
that “any amount”,
However,
i.e., as little as a single encounter,
it must be a large one so that the dose
13
It
could .be
the conditions are 1) one must first have expertence?
such an encounter, and 2)
pod |
that, with any amount of