OFFICIAL USE ONLY of a new canal (to replace the present Panama Canal). Dr. Lloyd Tepper, of DBM and the Division of Operational Safety, discussed some problems in connection with the supply of DIPA (diethylene triamine pentacetic acid) to AEC installations. DTPA, which is highly effective in the removal of unbound plutonium, is presently supplied by the Geigy Chemical Co. as an investigational drug. Geigy is not interested in marketing DTPA as a new drug and the question arises whether the AEC should undertake chronic toxicity tests required for Food & Drug Administration accreditation. While the AEC could request exemption from FDA control, it was felt that a reasonable temporary solution would be for the AEC to stock and distribute DTPA directly to its various installations and contractors. Dr. Tepper indicated that in this way the drug could be kept on an investigational basis for a prolonged period, The ACBM concurred with the latter proposal and also suggested that DBM might ask appropriate Commission-supported laboratories to examine chronic toxicity of DTPA over the next few years, There was some discussion of the recent Rhode Island accident. In connection with this, the Committee expressed interest in further briefing by the Licensing Division. The ACBM suggested that it might be useful for DBM to provide potential and actual investigators on AEC contracts (offsite) with a manual describing its review procedures. The Minutes of the 105th meeting were amended by addition of the following sentence to the last paragraph on page 2: "Subsequent information indicates that the diagnosis of carcinoma may have been incorrect in each instance." The Minutes of the 106th meeting were approved as circulated, The 108th meeting of the ACBM is scheduled for March 26-27, 1965 at the Pacific Northwest Laboratories, Richland, Washington. The 109th meeting is scheduled tentatively for May 14-15 at the Jackson Laboratory, Bar Harbor, Maine. Respectfully submitted, /s/ Harvey M. Patt Scientific Secretary, Advisory Committee for Biology and Medicine OFFICIAL USE ONLY -~ 3 -