ys Figure3. Withimmunofluorescént staining a dark cytoplasmic reaction product, indicated by the arrows, can be seen localizing prolactin in cells of the pituitary adenoma diagnosed in an exposed Utirik woman (No, 2160X). Prolactin-secreting cells have round-to-oval nuclei and distinct nucleoli (x800). incidencerate in the exposed Marshallese, based on a totalof 4252 observation years, is 17.8 times that recently reported from Olmsted County, Minnesota.”’ In the same study, women between the ages of 15 and 45 years had an incidenceof 7.1/100,000 personsper year. Theincidencerate in exposed Marshallese womenin the same age group (which includes the two patients discussed here) and based on 2176 observation years is 13.6 times the Olmsted County incidence. The following table provides relative risks, p values, and approximate confidence intervals for women between 15 and 44 years of age and for men and women combined whoare less than 45 years of age, with Olmsted County used as the referent population: é Marshall Olmsted Relative 95% Confidence Interval p Value 2 2176 11 163,096 13.6 (4, 42) 0.01 17.8 (6, 53) <0.001 Islands Women 15-44 yr Incidence: Person Yrs: Tot.Pop. Incidence: a Person Yrs: Cv Cc% C2 7 < 45 yr 2 4252 County 12 454,472 Risk