Our clinical. . well as the animal
is a narrow margir. .- tween the amount of
» Seem to suggest that there
4°4I which will promote abnorml cell
division (and perha;s promote neoplasm formation) and the dose of 1317 Bich
Leukocytes in Man following
5
Aremalies of Chromosomes in Circula
Voses
The first published observations in this
will
Therdpeut:
on chromosomal a
following large doses of 131I far carcinoma of[tte
thyroid ware made under this contract.
These cbheervations were made follp
167 millicuries of 1311 for carcinomaof the thyroid. Not only was there
BE
-
iy
:
:
i
acute dramatic rise in the incidence of anomiies (amounting to almost o shale
of the circulating leukocytes cultured at the height of the rediation ¢ fect),
but the pewliminary observations on that patient before the 167
curiks were
given showed a higher than normal initial incidence of ancmmlies. This RE
apparently attributable to residual effects from massive doses of 1311 that we
had given six years before. Since that time, we have attespted similar opec
include chromtids
breaks in one leg of a chroncecme, which my be artifacts
and to which (along with non-modal counts) we formerly attributed more s:
iCance.
David Satcher, aM.D.,
aspect of the work with
FaeD.
candidate, has been
on
the assistance of Dr. Neil Macintyre with whom we
published the first work.
‘The significant feature of the
Tha responsible investigator has recently spent five weeks in the
5
Eo
is
argha
;
in the anmual review of the Marshallese eased to tik
fallout from the thermonuclear devise detonated on Bikini in March 1954.
he