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1 July 1969 to 30 June 1969
RESEARCH PROJECT AT (11-1) 1784
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407560
TITLE OF INVESTIGATION
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A Study of the Physiological Function and
etn
uli
sal i
Radioactive Iodine
iistological Changes in Thyroids Irmadiated with
oythee ghia
SH iit
PRIICIPAL INVESTIGATOR
Brown i1. Dobyns, 4. D., Ph. D.
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Professor of Surgery, Case Western Reserve University
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Submitted 30 June 1969
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Case Westarn Reserve University School of Medicine
at Cleveland Metropolitan General Hospital
Observations have continued in a variety of areas in both =.0. md
as previously outlined and reported in great detail one year a>.
ani
’
Effects of 1311 Irradiation on the Thyroid in Clinical Subjects with 2
We continue to collect very detailed data on selecte. patimts treated wit
131I for hyperthyroidian 90 that the clinical effects of the 131I can ulfimately
be related to the behavior of 1511 that was observed in that individual.
This :s
done in an effort to get a better understanding of why the effective dos cof 1527
per estimated gram of thyroid tissue is so variable from individual to idividcz
Inspite of therapeutic doses, which are calculated to be just sufficient [to brig
the hyperthyroidian under control, we still observe far too high an incidens
y
i
of
» not weeks or months, but years after the mdiation is deJivered.
Since the responsible investigator is in charge of all 151I therapy in tps
hospital, these is an oppermmity to study selected patients in great det}
The following observations are made:
1)
Careful pretreatment charucterikatico
of the glard and the patient, not only with respect to the uptake of a traces
of
131], but a variety of observations on factors that may explain differengs amrg
patients.
2)
Determination of the amount of the treatment dose taken
up by the
thyroid, followed by almost daily measurements over the gland thereafter fo
determine the disappearance curve of the isotope from the glard.
3)
ripe
observations on the concentration of 131Z in the serum as it relates to the
thyroid at given times.
4%)
Determination of the extractable and
non-extheccab
fractions in the blood (butanol) and in same cases the serial quantitative
Getermination of iodinated compounds in the serum as the madiaticn effect!
takes
place. 5S) Similar observations are made on the total urinary excretio pf +311
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