Table 20
Growth and Thyroid Studies in Subjects With Thyroid Abnormalities
Neck '*7I
at 4 hr,"
% of dose
Growth
Subject
No.
and sex
Thyroid
abnormality
3M
Atrophy
3
M_
17
Year
tested
Chronological
age, yr
Skeletal
ranking,
yr
Statural
ranking,”
percentile
Pre
TSH
Post
TSH
Serum iodine,
ue%
PBI
1965
13
3
<10
Atrophy
1965
13
D2
<10
F
Nodular
1965
15
13%2
90
6.8('64)
21
F
Nodular
1965
15
15
10-25
8.1(°64)
69
F
Nodular
1965*
16
16
2
M
Nodular
1965
13
20
M
Nodular
1965
72,
F
Nodular
goiter
42
F
61
goiter
goiter
goiter
1966
1966
1966
1966°
1966°
08
1.9
0.8
3.1
<0.5
440
5.7
1.7
125
7.1
19
Adult
25-50
1965
18
17%2
>90
Nodular
goiter
1965
1966
15
13%2
10
F
Nodular
1965
20
Adult
50-75
54
M_
Nodular
goiter
1965
1966
13
13
90
19
M_
Nodular
goiter
1965
1966*
17
15%2
10
36
M_
Nodular
1965
19
18
75
4.1
33
F
Nodular
goiter
1965
1966
13
13%2
>90
65
F
Nodular
goiter
1965
1966
13
10%2
<10
59
F
Solitary
nodule
1965
1966
35
64
F
Carcinoma
1965
19664
31
40
M_
Solitary
nodule
1965
40
goiter
goiter
goiter
1966
1966
119
372
1.3
18
159
<0.5
25-50
19667
>120
248
1.8
6.5
1.0
TSH,"
ng/ml
1.8
112
goiter
-
>90
1.4
3.2
8
T,I
Serum
(29)
(23)
7.9
4.2
(31)
(3h)
65
4.2
3.2
2.6
9.6
26.6
5.3
(15)
(24)
3.7
4.6
12°10)
(24)
7.9
4.9
8.3
5.0
4.3
<3
<1
3.9
3.3
<7
4.2
4.3
<17
3.8
73
197
6.6
235
19
(16)
(24)
7.0
59
17 (9)
(14)
4.9
31
2.1
1.9
7°(20)
(38)
8.2
8.6
5.3
4.8
(19)
(28)
8.6
4.9
3.4
2.0
:
<17
10.3
@Values in parentheses obtained at BNL.
>Relative statural growth expressed as percentile ranking compared with growth curves of unexposed Marshallese
children.
‘Assays in 1965 could not detect levels below 3 nanograms/ml. Seven unexposed children in the same age group had
<3 ng/ml. Assays in 1966 could not detect levels below 17 ng/ml. Three exposed children without thyroid disease
(Nos. 6, 8, and 32) had <17 ng/ml. Two children exposed tn utero (Nos. 84 and 86) and two unexposed children had
<17 ng/ml. The 1966 levels were obtained about 3 weeks after cessation of thyroxine therapy, the 1965 levels. betore
therapy wasinstituted. We are grateful to Dr. William Odell at the National Institutes of Health for carrying cut these
assays.
‘Post partial thyroidectomy.
“While taking thyroxine.