. ry Senerae fi 27 Ganpaiion af Pediatr Groupe 2 No. feta Aur al cApmmue, 41 Kesieelap group <W bu 1% fa uters oNalinngiiae greauge <0 Vresposedd group Hoon te Pb. Lb Mheonsy LEG LONE +L ¥ * 3 9 t 2 4 22 he VW 7 skeletal development Cleft hand and wrist) wis Wibod. |) and systematic dea usncitadon of athe thropotetric data was started. “The documents. thon was continued ducing the succeeding exams 3. Growth Stotus laterpretation of the anthropometric data and avessmcnt af the growth atatus of the exposed Rangelap children have been complicated by (a) radia’ on injury tothe thyroid gland, (b) partial or tetal thyruidectusies in the children whe developed thyruid neoplasia, and (¢) the administra. Gon of thyroid horanone, to the entire exposed Kons uclap population since September 1965. If the nations on subjects comidered to be i ue growths phase (generally Uhreugh age 20). Vhe cata ree corded regularly (oaluded standing heat (state dlata on the three children (Nos, 3. 3, and 63) who ure), body weight. head chreundercence, head width, dead lenuth, chest cireuisference, bie acrornial width. and calf circumference, ana spare racheally included sitting height, chest width, chest depihy and buttocks cireuiicrence, (see Appen-: clin 7.4 The development of secondary sex characters bues was qualitatively assessed according to the sLandrd criteria generally gecepted ins growth studies (Greubc tet ab. Shuttleworth 3). Such virks procedures inehided the staging of breast devel- Fad in Section 1V. The other physical findings, which have been carefully tabulated in the individual reports for each survey,indicate no definite pauern of abnormalities that would differentiate the exposed children from the unexposed comparison children. The usual spectrumof infectious and noninfectious diseases, congenital anomalies, and physiolagical variations has been noted in both exposed and unexpased children, opment in ginks: estimation of the type, pattern, and auiountof body hair (facial. pubic, axillary, cle and staging of the growth of penis and totes in bows. Duriag several cxaminations, plates wistpliie dloviaineniation was done as portale the Jawan ab grow ib stats acl pits siquie. Vhe socntgcnographic evaluation of skeletal dovelopineut was dene by the Thapes tional teehee nique af Geeulieh and Pydet! aad the Ninericsan standhareks ware tiscd for canipar isan, 2. Physical Findings Vhe carly post-oy posure cssnatiations indicated Tet the voutwer childeen, in geacnal minifeied Hore extebsive and more severe radiation injury were obviously hypothyroid and had markedly salt body measurements are excluded, compansoos of mcan stature and skeletal age indicated no stulistically significant diterence between the ex- posed and unexposed children fur cither bovs or (aanpared with American norms, the incan skeletal ages at given chronological ages for each group were, for ubesxpescd girls, quite similar, but for unexpesed buys, thes appeared to be delaved by 6 te 7 months at cach chronological age. Earlier preliminary compa: isons had suggested that bays expased at age <5 sean were retarded it statural yrowih compared with unexpused bows, The current alalvsds excludes those with a spectic disagnonis oth poths roidisan Phe individual grow th and dev clopoieat carves for 14 children ea posed at ave OJcd their Controls ate shown in Figures 2) anal 22. Vhe etfect of thyroid treatment on the two bows (Nas. Sand d)is evident. Several other children (Nos. 2. 14.05, 42) had a tendeney to ward retarded development. which nav have been Ruproved by thyroid niecdication, On the dchildien exposed crater, caretal exam dnatiotas Pave resulted an ter uaaiisual polis sient fine. ings. The growth pregress af tof them bas been sbetnibaer tar ubiat ol ace peers (see Table Lo), One than the older children and adulis. Pollowtag recoveryfrom the acute clfece of radiation, the overall physical status of the children appeaced to be Vers Qa 8) has had a head circumference siballer than the average for unespescd males and asbahily retarded pacern of skeletal ataturation, thyroid albnocualivies, which are discussed below that of unexponed males. nocnal cxerpt for the subsequent development af but his statural growth curve was comparable with 2 . 4 2 oy ken ee oe ae oe ee CEesoe “Talabe 15