Crown Hematological Effects on Heavily Irradiated Japanese fisermen xPosed by tov ar Teactor ac al. 1956 os me ; TAsrer ANDREWs ct al, Ig Vearly 1 Tevealed the miMima] in : 3 ticalwee on st Nn j severe Cases, wWhj oe 2 reticulum cellsS. Fj Figure ven Comparing ° 100, > .. With nor: rma‘1 Gmantrs eTtcal stage = 20] (weeks gr YB anf a 0 og ¢ = 59 E 394 l year contrcl 3 20 Leukocytes of Bikini patients (J) (cumulative). * 6 years 2 aol Fig. 4 69 0 ve ro , _, 12345 6 7 £ $ id331213 leukce,tes < 107 * x 103 12]- a, > ee . 7 a ; — 7-3 : é . ” -~ Ne steht . wT Nee . or," * ” ° “ed. ~ “o. “Ag, a! . + e “dee ic fice S at Sth Week. ot i Marrow y4 Complete 8 not apPl astsi; at the 33) > Bt 8 7 critica} St age ° a6 — igi! MOS AGN mal] Persons. ay Wat eMarkah) . 7 in nor ys After one TAR : Fig. 5 . Changes in the numberof leuko- Ss = 4 cytes, neutrophils and lymphocytes. 3 i) = _ . wn, ZY i 07 147 23426070 6 123.456 78 S10 12131415 days months years time after exposure of normal Japanese. In the case of erythrocytes, 2 years after the exposure, the curve approximately came back to normal. A similar tendency is seen in the cumulative distribution curves of platelets. However, in a few cases slight neutropenia is still observed. Figure 5 shows the changes of total leukocytes, neutrophils, and lymphocytes of 2 cases which are representative for severe injury. A small increase of “mitotically connected abnormalities”, i. e. karyomeres of erythroblasts, were observed in bone marrow smears of a [ew cases after 10 years. Cytogenetical studies have been performed since several years. The results are summarized as follows (IsHizana and Kumatoni 1965; 1967; 1969). I. The frequency of aneuploid cells was 2~3 per cent, which was not