tiate that

t

=
=

laisini

to nolaaeat®«edd Yo 3 omi3 wns Je noijnaist1 “hod ytonw

time post onset: of:uptake, days,

d

instantaneous fraction of atoms decaying per unit time, day”
a

p?

initial atom ingestjon rate, “atoms day~!,
tf

instantaneous fraction of atoms removed from compartment. i by

ated

a

- ames

dads

-7

am

physiological mechaniems, day™‘,

db

Vdivilvan

eooune dun deni

fe

compartment i deposition fraction,

the number, of atéus ’in “compartment ‘i‘ gelat¢ive.to the number in all
is

|

compartments atthe onset of declining continuous uptake, (c#0),
pes

PP

BA

8

SETCOS tha tote wy!

instantaneous urine activity concentration, Bq 2™*,
:

subject urine excretion rate, & day”*,

ia

wes

et Dana

~~]

.

‘

VGalb

at

fraction fromGl; gest .to bloods; 4+..4,,
oo,
"
ee Gh |

fraction excreted by the urine pathway,

/

wt

instantaneous fraction of atoms removed or added to the atom uptale
*

tao

Ted 1G

per unit time, day” 1 due to ‘ factors"o ther’ than’” padiogeive |‘decay,
:

wit

i

at "EMA

instantaneous body burden, Ba,

o

itt

wn

sit

body burden at the onset of uptake, Bay

eng

‘

yet

3

idgt

elit sh

a

ara

4

i

the number of disintegrations in all compartments occurring durin,
the uptake interval, Bq days.

The development of Eqs. (1), (2), and (3) wae based on the following ciivolution integral.

At some variable time, T, defined during « fixed uptake

interval, T, the daily activity ingestion rate crossing the gastrointestinal
tract to blood is given by
Af P

o

e

-(kgtA)t

.

eo

i

“

fre

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