AO dyn and oe OO Rm SRme aoenalE ae et OU ME, an April 27, 1964 Herbert N. Hultgren, M.D. Stanford Medical Center 300 Pasteur Drive ‘ Palo Alto, California Dear Herb, It was a pleasure to read the manuseript of your new paper, "Farther Studies of High Altitude Pulmonary Rdema". It is an excellent presentation and together with your first paper will be a highly significant contribution. I have very little to offer in the of suggestion or criticism, because you have done a very Rough and convinaing gob in presenting your conolusions and supF ting evidence, e only question I would raise concerns Item "b" on page 13, which does not seem entirely clear. It suggests to me that ‘there is an elevation in plasma v&lume at . high altitude, whereas | we know that in both fully. acclimatised natives and in per= song undergoing acclimatization, plasma volume as determined with both radioiron and radiophosphorns, is :@n slightix lower at 15,000 ft. than at sea lev the average My recent data for 17,000 fte show a substantially lower plasma volume, I kk the liberty of asking Howard Parker to look over the mafisoript because he is deeply concerned with the problem, and I thought you might like to have his comments. I mene Closing a copy of his comments on the papers Both Howard and I would like to have reprints of this and your first paper when they are available and would appreciate being placed on your distribution list. , We are also looking forward with great interest to the are weet studies you are under this summer in Peru, If you con= — taet the group in the Institute of Andean Biology. please give’ my warmest regards to Dr.'s Hurtado, Pison, and e Raynafarjes ‘ Wetze “ONle. . ( id OS ne TEEGP Sincerely, T COPY AVAILABLE 3008255 | WYansirz ‘