SUMMARY REPORT yor RESEARCH PROJECT AT (30-1)-1243 seaass 1 August 1951 to 1 June 1971 ee 5 tiie SUEMITTED 30 June 1971 3 if 3 iZ TITLE OF INVESTIGATION apie A Study of the Physiological Functionand Has LE Radioactive Iodine hae i i 3 i : Ut 3 a : 2] i ii i FE 5 2a ashi 407557 Histological Changes_in Thyroids Irradiated with PRINCIPAL INVESTIGATOR Grown M. Dobyns, M.D., Ph. D. Professor of Surgery, Case Western Reserve Universi INSTITUTION Case Western Reserve University School of Medicine at Cleveland Metropolitan General Hospital This has_been a broad investigation of physiological and :“ppholog] produced by 1317 in the thyroids of animals and man. Tre work <7 1949 under an AEC contract at the Massachusetts General Hospital, Bosto under that contract. In 1951 the principal investigator moved to Case ' University where the present contract began. charges began =2 _Tthe Weste=zn Reserve: Various types of observations have been in progress at the same to the variability and availability of special clinical opportunities te the use of 1317, owing to the necessary time intervals between observations on animals and in man, and owing to acute demands on re when unique opportunities arose, efforts have been directed in diff depending on the circumstances that existed. The personnel engaged in continually occupied with different aspects of the project depending on of circumstances. Indeed, the collection of material from irradiated and the study of these individuals has extended over many years in to collect enough data to permit satisfactory conclusions. We mist be contimually fooled wp to go into detailed study each time an opportunity arises, but remain occupfed with cther more elective animal studies when circumstances are not pressing. The study of the morphologic changes grew out of the first observations on ah, treated thyroids in man. A good many years were spent developing vari methods of t a te column and paper chromatography for the separation of iodinated compo when these methods were not available. These methods were used to stuity changes in the amounts of these compounds in blood and in thyroid tissue]in normal anc irradiated thyroids. Extensive and detailed observations were made by on selected patients at the time of 151I therapy, and the information reference as follow-up information was cbtained on these individuals th