Hematological
and Maartnetti, 1956; Gusxova and BatsocoLov, 1956 ; ANprews et al., L961 ;
JamMet, 1961), it is noted that all these cases similarly revealed the minimal
value at about one month after exposure.
Bone Marrow
The bone marrow was aplastic at the critical stage in severe cases, which
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Bone marrow of one of severe cases at 5th week.
bone marrow a lack of bone marrow cells was observed.
With the begin-
ning of recovery, aplastic marrow changed to hypoplastic and then turned
into a type of maturation arrest. In some cases, recovery was not complete
even after one year.
In less severe cases, the bone marrow was not aplastic
but hypoplastic or in a type of maturation arrest even at the critical stage.
Morphological and Functional Changes
.
Several morphological abnormalities were observed: nuclear debris of
lymphocytes, binucleated lymphocytes, vacuoles of neutrophils, toxic granulations
of neutrophils, degenerative changes of blood cells, mitotic abnormalities of
erythroblasts, etc.
Motility and phagocytosis of neutrophils decreased remarkably. After one
year, in some cases these functions were still lower than in normal persons.
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FOLLOW-UP STUDIES
As above mentioned 16 to 18 fishermen have been examined on an annual basis.
Figure 4 shows the changes of the cumulative distribution curves of leukoevtes. The curve of critical stage appeared displaced far to the left of the
normal curve, and gradually approached normal values.
However, the curve of the 6th year was still displacedslightly to the left
Fig. 5
Changes ir
cytes. neutrophils
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cm ee
showed remaining andproliferation of plasma cells and reticulum cells. Figure
3 shows the bone marrowof oneof the severe cases. Comparing with normal
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subjects, i.e. Hiroshima cases, Marshallese, and cases exposed by reactor ac~ cidents (HEMPELMAN et al., 1952 ; Amano, 1953 ; Cronkite et al., 1956; Haster.ix
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T. KUMATORI
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However,
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A small
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10 years.
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