NtéG, verles v _——C an _ hist Gy Not Authorized for Pubtic Release By: Date Date: Date: 7 OpenNet Enter By: i By. - Howard Brow Ther 1be Oe L. W. Tuttle SFT the fl , R ) the effects of radiation constitutes a significant advance in the field. Tha investigators found that the ted essential wos ie f 4 a aubstance which is widespread in most organiens and which multipls fatty acids which are intiuately concerned withgrewth ani new osll formation, when irradiated underge a shift of the isolated double bonds into conjugated positions. This bamil shift is a measure of . 160 INFO 8 Kar KETED FICATION REVIEW DEPARTMENT OF ENERGY DECLASSI N [C IRCLE NUMBER(S)} INATIO DETERM > SINGLE REVIEW AUT HORI CATION RETAINED CLASSIFI 1, th TO; Art S$ sat 56, Ott 2. CLASSIFICATOA CHANGEDIFIED IN 3, CONTA NS Roy DOE CLASS WITH: NATE REVIEWER {ADO): SOR x LAs tf CATION CAH uA free radical and consequent peroxide formation in the acids molecules. Appropriate calculations showed that thie pghenomencn takes place with an ionio yield of 16 which ia very high and shoes that e chain reaction similar to auto-cxidation must be taking place. Further experinents are underway toward determining the nature of the reaction and its products and a determination of the effects of these irradiated _" oe se products upon living systema. poam@ia to stetilizse food products by the use of irradiation frou fission products. ed na OO ne Related fundamental studies on the influence of fonizing radiation upon pure organic metabolites and the effect of wame: Ae Koc8A"l te Information of this nature is of vital importance in determining the possible hesardaz involved in the pro- ee Zfi¢ » : awd Investigators at the University of California at Los Angeles projeat — have recently made a very fundemental concerning the mechanism by which ionising radiation damages biological systens. It is well known that dosages of radiation which exert profound effecta upon living organisns have almost undetectable action on moss pure chemical substances. For thia reason the that , = i + ’ 1 f JULY PROGRESS REPORT ~ MEDICAL BRANCH FG,Ghding ‘6d for Public Release OPENNET ENTRY , these radiation altered metabolites upon living systems has recently been initiated at Reed College, Portland, Oregon; University of _ California at Berkeley and the University of Michigan at Ann Arbor. The objective of these studies is to provide basie information cone cerning the safety or non-safety of the eonsumption of highly irradiated food products prior to the time that the technologic feasibility of using fiseion products to sterilize foods is established. _f 4 : Ws w fed? BEST COPY AVAILABLE BIOMEDICAL PROGRAMS IN WEAPONS TESTS aisninaeeplantgs I By Commission action the Division of Blology and Medicine has been given responsibility for the “soordination and sersening of proposals from all agentes for biasedical experiments and eivil defense programs as well as similar proposals from within the AEC organisation. Recommended proposals will be referred to the Manager, SFO, through the Division of Military Applications for comment on feasibility. Acceptable and Lz tees OFFICE > SURNAME } DATE > ie 8s .