.
1
leg in normal aice and mice
and
4
tthe
receiving 1000 rad in a
rad increments 24 hours apart.
the
after irradiation and
|
per leg.
> skin
> skin.
the mice
receiving a Single
.
-
Loot
dose or
aes
LUG,
I Jet tee + oles
ea a “
200,
single dose or 1Q0UC rad
All 1000 rad animals dieu
ce
or 3gu raa
in tour 254
by
wie
Lith gay
very low CFL-S content of abuur |
survivors had a
Animals receiving a 25u rad dose at 24 hour intervais hac an
od
equal depression of
~
near normal levels
their CFL-S, followed by an exponential reccvery to
by 30 days after exposure.
ae
Therapy of whole Body Radiation Injury
oe
bacterial
:
death in
eased
74
living primarily
the
a
kill the animal that is irradiated in the LDg, range (11, 2b, 38-40).
ve
use of antibiotics as an eftective
trial
:
al.
(41)
irradiated animal
with
in
in the LDso range.
tite major cause ot
ulation
‘he dose
the
infection has long been established as
the gastrointestinal
The commensal organisms
tract are
treatment was
the
usual organisms
that
The
first shown by Miller et
the administration of streptomycin in mice.
In addition,
, in the
aN
germ-free animals have been studied (42, 43) ana
unction
2 .
dying irom hemorrhage and anemia rather than infection in the absence of
pacteria.
The effectiveness otf antibiotics falls oft
jethal dose
level since
marrow reeeneration ensues.
to
the antibiotics being used
Taketa (44) has
of water-electrolytes and antibiotic
radiation death in
the
rat.
In
rat,
and
intensively
therapy against
these studies
aicroorganisms play a prominent role in
the
antibiotics,
nears
to rodents.
Dogs have
the use of
been
fluid replacement, and blood
studied
it was clearly
the genesis of
this was modified by
before
the acute
latensive administration of water and electrulytes.
effect not limited
as one
the 106u4
bone marrow regeneration is delayed so long
bacteria develop resistance
death in
tnese anisals live longer,
acute
that
bone
the roles
mee
4
a
intestinal
shown
that
intestinal
antibiotics and
It is a beneficial
treated with success with
transfusion.
A dramatic
feprovement in mortality was obtained by Coulter et al. -(45), Hammond (46),
HB and Allen et al. (47).
In the latter study, blood transtusions were
combined with success{ve antibiotics.
{erally irradiated mouse,
therapy upon
cm doses of
the
the intestine are frequently cultured
the mortality
radiation were
vgs Weatment resultea
Webster
(48) tested
from whole
body
used from 700 raa
fact
from
the
the eftect ot
x-irradiation of
through 2500 rad.
in significant prolunyaticn of
the mean
that commensal
blood of
sy
aeFn,
——e
3
rats.
=,
me
Te
=:
survival
reege
it
Graded
Seomycin
were
weate
et
Se TEATS
Tae
ee Tom,
eke
vfeeeaeOre
eaeA pitta:
aie,
ard
CO tt a
yates
wate
the
oral neomycin
-105-
ah
Stganisns of
in view of
Te
time of
pennyaanenayewErreneOtSa
we.
.