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INTRODUCTION
From perusal of the older literature and review of the Japanese
experience at Hiroshima and Nagasaki (1), it appeated necessary to consider
some broader aspects of radiation injury in general,
produced by radiation injury,
such as the syndromes
the influence of depth dose of radiation,
unresolved question of lethality of radiation in man,
rate, and repair of injury during chronic exposure
fallout fields decaying with the -1.2 law.
the
the role of dose
to radiation as in
Studies on pure radiation
injury generally involve a single dose of x-ray or gamma rays at different
dose rates,
and
it is
rare
to find sufficient data
to evaluate
the
influence of depth dose patterns within the experimental subject.
considers the numbers of animals used,
the steepness of
radiation lethality curve between 10% and 90% mortality,
studying animals exposed to single dose of radiation,
When one
the sigmoidal
the practice of
one must consider the
possibility that lethality differences observed may represent chance
variation, not related to any therapy used.
evaluation,
In a retrospective literature
these are questions that cannot be evaluated definitively.
In
Whole-Body Irradietion:
ite
se
:
os
AE
Fh
atterns which will be considered later.
Three, somewhat arbitrary ana
The Central Nervous System Syndrome
After
large
deses of
several
NS) syndrome is produced.
thousand
rad,
ra
MES ee ee
shes
:
ed
wea Tet
The radiation syndromes produced by exposure to fonizing radiation are
Pa
tihpe 3%
SERED 58h
et
Kkadiation Lethality - The Classical Syndromes Produced by Uniform
;
atts
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LTA
to the antibilotics available,
1 a
‘tesistance
ick
Aap
Ae5
nil t
*
_fegenerate before the commensal or invading pathogenic bacteria develop
ee
the bone marrow will
the Central Nervous Systen:
Death may occur during exposure in some
-93-
+
:
3
3
os?
of
A crucial problem in radiation injury is whether
ei
ton
trauma and individuals with tenporary marrow hypoplasia.
~
ok
extensive burns,
eee e nepe
on
*
stated that antibiotics increase the survival rate of patients with
ee
emf
aplasia produced by agents other than radiation, it can be categorically
2 pons ee
aa eT ate
Be tee
trauma and thermal burns in nan aud formanagement of marrow
——
Pearse sree fT, sclare
: ee
et
management of
CR ongapelEietiten food sehttorenitarareneciel
x
pe
respect to therapy, vast human clinical experience on use of antibiotics in
p
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erates
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ey war Fear erere