oe ae ~pt
TR
eS
F
Geuth was ascribed
ss
‘The curve
The next
snowed infection and hemorthage as causes of
the granulocyte count hag a
least decline in
the
showing
the granulocyte count with a mortality of
in
The animals at autopsy
Geath.
aaa Eee ee
to intection and cumplicated by henerrhage.
curve shows a slower decline
aC%.
ph.
e
muttality of 10% with hemorrhage and infection
In Figures 3 anc 4,
the critical
role‘of
the causes of death.
the ,ranulocyte count in
Japanese ag a oeterminant of mortality is illustrated.
the
i
Figure 3 plots the
q
‘
mortality against the blood counts observed in the third, fourth, and fifth
weeks.
fron
"orem 1
The
lower
the white count
the higher
the sortality.
Figure 4
“
t
cortelates the mortality at the end of nine weeks with the lowest white
The most clearcut cotrelation of
count observed,
the
infection is in the work of Miller et al. (26), shown in Figure &.
figure,
there
is a clearcut correlation of mortality with
animals having positive
studies
in hussia
and
p:
importance of
In thig 2
gr
the
fraction of
4
wh
blood and splenic bacterial cultures.
Subsequent
¥
ex
of
ex,
the L.S,
extena and confirm
the
rele
of
infection,
Liluwanian and Izvekova (30) have studied a whole series of antibiotics and fa
thezr use
in the
treatment
of radiation injury
a
They administered kanamycin,
i
oxacillin,
:
by mouth for a
as
a
!
ana
wletetrine,
Une antibiotics
rats, ane rabbits, * 2
tetracycline,
were
rays.
(33
ampicillin,
administered
total of 20-25 days starting 24 hours after
lethal dose of gamma
effective
erythromycin,
in wice,
twice
fal
a day “J:
exp-
irradiation withs :
fron
A coubination of antibivtics Was nore
than single antibiotics.
erythromycin, or
such
The combination of kanalInycin with
is ]
.
tettacycline o1
tetracycline with ampicillin was most wx|
;
effective.
f
,
more than 50% survival. _ Chernov et al. (31) and Trushina et al. (32) Sige
administered nexamine prior to exposure of dogs and nonkeys followed by.
50% pb
ceome
administration of antibiotics.
exper:
The antibietic combinations changed a near
streptomycin were
used.
100% mortality, ‘te
For ,
In the case of dogs, penicillin and
The survivals
increased from 11% to 69%.
studies on monkeys, a combination of kanamycin,
and penicillin was used,
X-re.
oletettrine,
:
phante
streptomyed
4
There was an increase in survival from 20% ta
y.
SP the
5G% «
The Effects of Geometry of Exposure and kadiation Injury on
Lepth-Lose
The
Curves
and
inadequacies of
be illustrated by showing
biolugical
Lffectiveness
using an air douse of
the
¥
7
radiation for prognosi@RE -
influence of exposure peonetry and enet
: . the
°
the
Bense
ae 7 gathe
t
ing