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a
dt
c
A
T
UPTAKE
6
CONTENT
=>
t, TIME
Since the retention of each element cf uptake is independent of all others,
the activity taken up during the whole intake interval which reuwins at t is
7
t
q (t) = \ UCr) re (c - t) dt
(1)
°
The rate of change of q(t) will be the result of flow rates into and out of
the systemic region
oo) u(t) - E (tr) - ag(t)
Aq(t)
u(t)
systemic excretion rate,
Ut
where E(t)
decay rate of systemfc activity, and
systenic uptake rate,
(2)