- "Durbin": Alpen/DOEcorrespondencere: Durbin project "Radionuclides in Monkey
Tissue" 1978/1979. "... treatment of plutonium toxicology is not a high-priority problem
for DOE..." [see also "Raymond" for Alpen's memoto Dr. Kenneth Raymondonthis
subject].
Durbin correspondence to DOEre: above project having been terminated
8/79 [see also "Shanahan”for Alpen's memoto W.J.. Shanahan which refers to a new
project that "replaces Durbin's Project 4432” on Radionuclides /Metabolism/Toxicity].
- "Everette": cc: of memo from R.H. Thomasre: "Radiation ExposureIncident- July 27,

1978" ["Biomedical beam room 1 (B1)"].
- "Frey": Alpen to Charles F. Frey, Chief of Surgical Service, Veterans Administration

Hospital, Martinez, CA,re: "... radiotherapytrial of heavy charged particle beams
including helium, carbon, neon and argon ions. Among the tumortypesto be tested are
localized, unresectable cancer of the pancreas without evidenceof intraabdominal or
distant metastases." " ... exploring possibility of collaboration with the Veterans
Administration Hospital system in either of these areas."
- "Heyman": Correspondence between Vice Chancellor Ira Heyman, Alpen, David S.
Saxon [President, UC Systemwide Administration] re: medical care for human subjects
injured during research. Mainly covers points on UCliability.
- "Lindgren": Includeslist of Donner Laboratory Seminars for 1975 and 1976. On
9/22/75: Dr. Patricia W. Durbin on "Reassessmentof the Distribution of Plutonium in
the Human Body Based on Experiments with Non-HumanPrimates."
- "Meyers": Alpen to Frederick H. Meyers, Professor of Pharmacology at UCSF,

8/23/78. Meyers believes the drug 4-Bromo-2, 5 dimethoxy phenyl isopropylamine [an
amphetamine, Schedule 1 since 9/73] "was not investigated in human beings without
properclearances and reviews." Alpen states the protocol "was submitted by the
investigators to the LBL Committee for Safeguards in Research on HumanSubjects. The
committee membershipat that time wasas follows: James Born, MD,chairperson,
William Siri, Ph.D., Howard Parker, MD, Thomas Budinger, MD, Ph.D., and James

McCrae, MD. The committee reviewed and approvedthe protocol, and the work was
conducted as outlined. Further review, not required by law or regulation, by the UCB
Committee on Radiation Safety was also requested and concurrence received from
them.

"

Attachedto this:

- Meyers’ photocopyof item from The Toxicology Newsletter describing
death/injury from this drug, with handwritten note: "This is a Donner compound

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