5] TX, URANIUM Summary Natural ly occurring, uranium has an exceedingly long half Jife and anits alpha particles. It is concentrated in kidney and bone. Uranium has been the subject of toxicological study for many years, and its nephrotoxic properties were known a century prior to work on its radiobiological significance. The chemical toxicity to the kidneys of natural uranium overrides any potential for radiobiologic toxicity. Only with high specific activity fsotopes of uranium is the skeleton at risk for subsequent radiation-related cancer _ development. Environmental Pathways Uranium (238u, 234, and 235u) is naturally occurring and is distributed ubiquitously but variably throughout the earth's surface. It is present in water and in foods, so that small quantities are ingested daily. The NCRP (1975), fran data of Welford and Baird (1967), reported an average Approximately equai amounts (about 22 percent) of dietary uranium were derived from each of four food groups: cereals and grains; meat, fish, and eggs; green vegetables and fruits; and root vegetables. About 7 percent was fron dairy products, and 2 percent was fran drinking water. Inhalation was considered to be a very minor route of assimilation. %s eg Peta ea, Spethat oe a tee The dose rate to bone fran natural uranium was calculated to he about 12 mrem/yr (NCRP, 1975). Thts value amounted to only about one-tenth of the total for skeletal tissues fran naturally occurring radioact tvity. Any urantum that {s released into the environment sich as that which dnes not undergo fission in a nuclear weapon detonation would be restored to the whee s see daily intake of 0.9 picocuries of uranium.