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Nickson (1948), in discussing needs for protection for those working with
radiofodine, pointed out the need for understanding the potential for cancer and
ergy ott hereey eyes +
other thyroidal effects that radioiodine possessed.
Later, Trunnel] (1949)
warned
The possibility of the development of neoplasms fifteen
or twenty years after radioactive fodine therapy should
preclude its use in al} but elderly or otherwise bad
risk patients.
Werner et al. (1949) also brought out the concern for subsequent thyroid cancer:
It {s feared by some that later malignancy may be induced
in the thyroid as a result of the effects of a radioactive
agent .--.
This ..- radiation ... makes it likely that
malignant degeneration in the gland may appear fifteen to
twenty years hence.
When Goldberg and Chatkoff (1951) reported the production uf tiproid tumrs
ow oP
in rats given 1311, they also emphasized the need for cautton in using
radfofodine in medicine.
In 1950, Duffy and Fitzgerald (1950) reported that several young patients
with thyroid cancer had received prior irradiation.
Later, Simpson et al.
(1955) and Clark (1955) reported on the association between relatively low x-ray
exposures and thyroid cancer in children.
Subsequent studies, too numerous to
reference in this report, but well represented by the long-term follow-ups of
Winship and Rosvol? (1970), Hempelmann et al. (1975), and Modan et al. (1974),
indicated that exposure of the thyroid gland to x-irradiation during tnfancy ant