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administration to a nursing woman (Miller and Weetch, 1955), to goats (Wright et
al., 1955), and to cows (Comar and Wasserman, 1956; Lengemann and Comar, 1956)
was shown.
In the last case, the radfofodine work was part of a study designed
to provide infornat ton about the secretion of fission products into milk.
These
Studies in people and large animals, however, were not published untf! some time
after the transfer of !311 through milk was used as a method to irradiate
nursing mice (Rugh, 1951).
After these early reports on the radiobtology of radfolodine, studies on a
national and international scale continued. The primary pathway of I311 to
people was recognized as being atmasphere*vegetat fon-cowmilk+people, and predictive models for this and other pathways have been deve] oped (Soldat, 1963; Ng
and Thompson, 1966; US MRC, 1977).
The prominence of the thyroids of children
in the 13) l-milk pathway was recognized. A major symposium on radfofodine was
held fn 1963 (Bustad, 1964), in which were presented many papers on these and
other topics.
Studfes on the environmental aspects of radiolodine have continued to the
present, not so much because cf continued concern aver short-term fallout fram
nuclear weapsons, but more so because of the potential for radiofodine releases
frozr nuclear reactors.
Investigations {nto the chemical nature of the radio-
lodine have been made to identify radiotodine species in nuclear reactors
(Pelletier et al., 1978a, 1978), and evaluations of other fodine isotopes,
1291 for example (Soldat, 1976), have been made,
Metabo)tcPathways
The phystologica! role of {ndine, that {%, {ts concentration by the ther:
glamt and fts subsequent
'ncorparation intn hormmnes that are stored with
tw
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